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DB00307 : bexarotene

Approved drug bexarotene ... 3 targets DB00307

Generic name: bexarotene PDB Het Group: 9RA
 
2 structures in PDB
Brand name(s): targret, targretin, targretin-gel, targretyn, targrexin.
Formula: C24H28O2
IUPAC Formula: 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)ethenyl]benzoic acid
PDB name: 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)ethenyl]benzoic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P19793 (RXRA_HUMAN)  -  Retinoic acid receptor RXR-alpha
UniProt id: P19793    461 a.a.  
1. 4k6i A   214 a.a. 214   X-ray 2.10 Å
  2. 3h0a A   210 a.a. 210   X-ray 2.10 Å
The PDB contains 2 entries of bexarotene bound to this target protein and 56 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P28702 (RXRB_HUMAN)  -  Retinoic acid receptor RXR-beta
UniProt id: P28702    532 a.a.  
1. 1uhl A     214 a.a. 214   X-ray 2.90 Å
  2. 1h9u A,B,C,D     201 a.a. 201   X-ray 2.70 Å
There are no PDB entries containing bexarotene bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P48443 (RXRG_HUMAN)  -  Retinoic acid receptor RXR-gamma
UniProt id: P48443    462 a.a.  
2gl8 A,B,C,D     190 a.a. 190   X-ray 2.40 Å
There are no PDB entries containing bexarotene bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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