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DB00281 : lidocaine

Approved drug lidocaine ... 4 targets DB00281

Generic name: lidocaine PDB Het Group: LQZ
 
2 structures in PDB
Brand name(s): after burn double strength gel, after burn double strength spray, after burn gel, after burn spray, alphacaine, anestacon, anestacon jelly, cappicaine, dalcaine, dermaflex, duncaine, esracaine, gravocain, isicaina, lanabiotic, leostesin, lidoderm, lidoject-1, lidoject-2, lignocaine, maricaine, norwood sunburn spray, octocaine, octocaine-100, octocaine-50, rocephin kit, solarcaine, solarcaine aloe extra burn relief cream, solcain, xylocaine, xylocaine 5% spinal, xylocaine dental ointment, xylocaine endotracheal, xylocaine test dose, xylocaine viscous, xylocaine-mpf, xylocaine-mpf with glucose, xylocard, zilactin-l, zingo.
Formula: C14H22N2O
IUPAC Formula: 2-(Diethylamino)-N-(2,6-Dimethylphenyl)acetamide
PDB name: 2-(Diethylamino)-N-(2,6-Dimethylphenyl)ethanamide

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q9Y5Y9 (SCNAA_HUMAN)  -  Sodium channel protein type 10 subunit alpha
UniProt id: Q9Y5Y9    1956 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: Q15858 (SCN9A_HUMAN)  -  Sodium channel protein type 9 subunit alpha
UniProt id: Q15858    1988 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q14524 (SCN5A_HUMAN)  -  Sodium channel protein type 5 subunit alpha
UniProt id: Q14524    2015 a.a.  
1. 4dck A     153 a.a. 153   X-ray 2.20 Å
  2. 4jq0 D     142 a.a. 142   X-ray 3.84 Å
  3. 2kbi A     97 a.a. 93   NMR  
  4. 2l53 B     31 a.a. 27   NMR  
  5. 4djc B     13 a.a. 11   X-ray 1.35 Å
There are no PDB entries containing lidocaine bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P00533 (EGFR_HUMAN)  -  Epidermal growth factor receptor
UniProt id: P00533    1209 a.a.  
1. 3qwq A     613 a.a. 613   X-ray 2.75 Å
  2. 3njp A,B     614 a.a. 613   X-ray 3.30 Å
  3. 1nql A     612 a.a. 611   X-ray 2.80 Å
  4. 1yy9 A     613 a.a. 610   X-ray 2.60 Å
  5. 4kro A     570 a.a. 570   X-ray 3.05 Å
   more ...
There are no PDB entries containing lidocaine bound to this target protein, although there are 90 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with lidocaine bound in the PDB

There is 1 "non-target" protein in the PDB containing the lidocaine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P24627 ()  -  Lactotransferrin OS=Bos taurus GN=LTF PE=1 SV=2
UniProt id: P24627    707 a.a.  
3ttr A   341 a.a. 339   X-ray 2.27 Å
The PDB contains 1 entry of lidocaine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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