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DB00280 : disopyramide

Approved drug disopyramide ... 6 targets DB00280

Generic name: disopyramide PDB Het Group: DP0
 
1 structure in PDB
Brand name(s): dicorantil, isorythm, lispine, norpace, norpace cr, ritmodan, rythmodan, rythmodan p, rythmodan-la, searle 703, xi-disopyramide.
Formula: C21H29N3O
IUPAC Formula: 4-[Bis(propan-2-Yl)amino]-2-Phenyl-2-(Pyridin-2-Yl)butanamide
PDB name: Disopyramide

6
There are 6 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14524 (SCN5A_HUMAN)  -  Sodium channel protein type 5 subunit alpha
UniProt id: Q14524    2015 a.a.  
1. 4dck A     153 a.a. 153   X-ray 2.20 Å
  2. 4jq0 D     142 a.a. 142   X-ray 3.84 Å
  3. 2kbi A     97 a.a. 93   NMR  
  4. 2l53 B     31 a.a. 27   NMR  
  5. 4djc B     13 a.a. 11   X-ray 1.35 Å
There are no PDB entries containing disopyramide bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P11229 (ACM1_HUMAN)  -  Muscarinic acetylcholine receptor M1
UniProt id: P11229    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing disopyramide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing disopyramide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: Q9NZV8 (KCND2_HUMAN)  -  Potassium voltage-gated channel subfamily D member 2
UniProt id: Q9NZV8    630 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: Q9UK17 (KCND3_HUMAN)  -  Potassium voltage-gated channel subfamily D member 3
UniProt id: Q9UK17    654 a.a.  
1. 2nz0 B,D     136 a.a. 136   X-ray 3.20 Å
  2. 1s1g A,B     107 a.a. 106   X-ray 2.60 Å
There are no PDB entries containing disopyramide bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with disopyramide bound in the PDB

There is 1 "non-target" protein in the PDB containing the disopyramide molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P19652 ()  -  Alpha-1-acid glycoprotein 2 OS=Homo sapiens GN=ORM2 PE=1 SV=2
UniProt id: P19652    200 a.a.  
3apw A,B   175 a.a. 174   X-ray 2.20 Å
The PDB contains 1 entry of disopyramide bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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