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DB00274 : cefmetazole

Approved drug cefmetazole ... 6 targets DB00274

Generic name: cefmetazole PDB Het Group: 4KO
 
1 structure in PDB
Brand name(s): zefazone.
Formula: C15H17N7O5S3
IUPAC Formula: (6r,7s)-7-{2-[(Cyanomethyl)sulfanyl]acetamido}-7-Methoxy-3-{[(1-Methyl-1h-1,2,3,4-Tetrazol-5-
Yl)sulfanyl]methyl}-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylic acid
PDB name: (6r,7s)-7-({[(Cyanomethyl)sulfanyl]acetyl}amino)-7-Methoxy-3-{[(1-Methyl-1h-Tetrazol-5-
Yl)sulfanyl]methyl}-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylic acid

6
There are 6 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: C1KC03 (C1KC03_STAAU)  -  Penicillin binding protein 2a
UniProt id: C1KC03    486 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P02918 (PBPA_ECOLI)  -  Penicillin-binding protein 1A
UniProt id: P02918    850 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P02919 (PBPB_ECOLI)  -  Penicillin-binding protein 1B
UniProt id: P02919    843 a.a.  
1. 3vma A     708 a.a. 708   X-ray 2.16 Å
  2. 3fwl A     707 a.a. 707   X-ray 3.09 Å
  3. 3fwm A     666 a.a. 666   X-ray 2.16 Å
There are no PDB entries containing cefmetazole bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P0AD68 (FTSI_ECOLI)  -  Peptidoglycan synthetase ftsI
UniProt id: P0AD68    588 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P0AEB2 (DACA_ECOLI)  -  Penicillin-binding protein 5 precursor
UniProt id: P0AEB2    402 a.a.  
1. 3mzf A     355 a.a. 355   X-ray 1.50 Å
  2. 1z6f A     354 a.a. 354   X-ray 1.60 Å
  3. 3mzd A     354 a.a. 354   X-ray 1.90 Å
  4. 3beb A     354 a.a. 354   X-ray 2.00 Å
  5. 3bec A     352 a.a. 352   X-ray 1.60 Å
   more ...
There are no PDB entries containing cefmetazole bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P08506 (DACC_ECOLI)  -  D-alanyl-D-alanine carboxypeptidase dacC
UniProt id: P08506    399 a.a.  
1. 3ita A,B     348 a.a. 348   X-ray 1.80 Å
  2. 3it9 A,B,C,D     348 a.a. 348   X-ray 2.10 Å
  3. 3itb A,B,C,D     345 a.a. 345   X-ray 1.80 Å
There are no PDB entries containing cefmetazole bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with cefmetazole bound in the PDB

There is 1 "non-target" protein in the PDB containing the cefmetazole molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q9HV14 ()  -  Uncharacterized protein OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=PA4794 PE=1 SV=1
UniProt id: Q9HV14    159 a.a.  
4kos A   159 a.a. 158   X-ray 1.55 Å
The PDB contains 1 entry of cefmetazole bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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