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DB00273 : topiramate

Approved drug topiramate ... 5 targets DB00273

Generic name: topiramate PDB Het Group: TOR
 
2 structures in PDB
Brand name(s): topamax, topamax sprinkle.
Formula: C12H21No8S
IUPAC Formula: [(1r,2s,6s,9r)-4,4,11,11-Tetramethyl-3,5,7,10,12-Pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-
Yl]methyl sulfamate
PDB name: [(3as,5ar,8ar,8bs)-2,2,7,7-Tetramethyltetrahydro-3ah-Bis[1,3]dioxolo[4,5-B:4',5'-D]pyran-3a-
Yl]methyl sulfamate

5
There are 5 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14867 (GBRA1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-1
UniProt id: P14867    456 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P35498 (SCN1A_HUMAN)  -  Sodium channel protein type 1 subunit alpha
UniProt id: P35498    2009 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P39086 (GRIK1_HUMAN)  -  Glutamate receptor, ionotropic kainate 1
UniProt id: P39086    917 a.a.  
1. 4mf3 A,B     258 a.a. 258   X-ray 3.00 Å
  2. 3fv1 A,B     256 a.a. 256   X-ray 1.50 Å
  3. 3fv2 A,B     256 a.a. 256   X-ray 1.50 Å
  4. 3fvg A,B     256 a.a. 256   X-ray 1.50 Å
  5. 3fvk A,B     256 a.a. 256   X-ray 1.50 Å
   more ...
There are no PDB entries containing topiramate bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
3hku A   257 a.a. 257   X-ray 1.80 Å
The PDB contains 1 entry of topiramate bound to this target protein and 479 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 5:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing topiramate bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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