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DB00260 : cycloserine

Approved drug cycloserine ... 2 targets DB00260

Generic name: cycloserine PDB Het Group: 4AX
 
2 structures in PDB
Brand name(s): closerin, closina, cyclomycin, cyclorin, cycloserin, farmiserina, farmiserine, micoserina, miroserina, miroseryn, novoserin, orientomycin, oxamicina, oxamycin, oxymycin, seromycin, tebemicina, tisomycin, wasserina.
Formula: C3H6N2O2
IUPAC Formula: (4r)-4-Amino-1,2-Oxazolidin-3-One
PDB name: (R)-4-Amino-Isoxazolidin-3-One

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P0A6J8 (DDLA_ECOLI)  -  D-alanine--D-alanine ligase A
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: Q9L888 (ALR_MYCAV)  -  Alanine racemase
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:  

 

Other proteins with cycloserine bound in the PDB

There are 2 "non-target" proteins in the PDB containing the cycloserine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P10724 ()  -  Alanine racemase OS=Geobacillus stearothermophilus GN=alr PE=1 SV=2
UniProt id: P10724    387 a.a.  
1xql A,B   381 a.a. 379   X-ray 1.80 Å
The PDB contains 1 entry of cycloserine bound to this protein
Protein 2:   UniProt id: P35439 ()  -  Glutamate receptor ionotropic, NMDA 1 OS=Rattus norvegicus GN=Grin1 PE=1 SV=1
UniProt id: P35439    937 a.a.  
1pb9 A   281 a.a. 279   X-ray 1.60 Å
The PDB contains 1 entry of cycloserine bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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