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DB00259 : sulfanilamide

Approved drug sulfanilamide ... 1 target DB00259

Generic name: sulfanilamide PDB Het Group: SAN
 
4 structures in PDB
Brand name(s): avc, albexan, albosal, ambeside, antistrept, astreptine, astrocid, bacteramid, bactesid, collomide, colsulanyde, copticide, deseptyl, desseptyl, dipron, ergaseptine, erysipan, estreptocida, exoseptoplix, fourneau 1162, gerison, gombardol, hsdb 223, infepan, lusil, lysococcine, neococcyl, orgaseptine, prontalbin, prontosil album, prontosil i, prontosil white, prontylin, pronzin album, proseptal, proseptine, proseptol, pysococcine, rubiazol a, sanamid, septamide album, septanilam, septinal, septolix, septoplex, septoplix, stopton album, stramid, strepamide, strepsan, streptagol, streptamid, streptamin, streptasol, streptocid, streptocid album, streptocide, streptocide white, streptocidum, streptoclase, streptocom, streptol, strepton, streptopan, streptosil, streptozol, streptozone, streptrocide, sulfamidyl, sulfamine, sulfana, sulfanalone, sulfanidyl, sulfanil, sulfanilamide vaginal cream, sulfocidin, sulfocidine, sulfonamide, sulfonamide p, sulphanilamide extra pure, sulphanilamide gr, therapol, tolder, white streptocide.
Formula: C6H8N2O2S
IUPAC Formula: 4-Aminobenzene-1-Sulfonamide
PDB name: Sulfanilamide

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 3 
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P0AC13 (DHPS_ECOLI)  -  Dihydropteroate synthase
UniProt id: P0AC13    281 a.a.  
1aj0 A   282 a.a. 281   X-ray 2.00 Å
The PDB contains 1 entry of sulfanilamide bound to this target protein and 3 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with sulfanilamide bound in the PDB

There are 2 "non-target" proteins in the PDB containing the sulfanilamide molecule bound. That is, the UniProt code for the proteins is missing or does not match the drug target above.

Protein 1:   UniProt id: E8T502 ()  -  Carbonate dehydratase OS=Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1) GN=Theam_1576 PE=1 SV=1
UniProt id: E8T502    246 a.a.  
4coq A,B   225 a.a. 225   X-ray 1.55 Å
The PDB contains 1 entry of sulfanilamide bound to this protein
Protein 2:   UniProt id: O75643 ()  -  U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens GN=SNRNP200 PE=1 SV=2
UniProt id: O75643    2135 a.a.  
1. 4f92 B   1723 a.a. 1722   X-ray 2.66 Å
  2. 4f93 B   1723 a.a. 1722   X-ray 2.92 Å
The PDB contains 2 entries of sulfanilamide bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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