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DB00243 : ranolazine

Approved drug ranolazine ... 2 targets DB00243

Generic name: ranolazine
 
Brand name(s): ranexa.
Formula: C24H33N3O4
IUPAC Formula: N-(2,6-Dimethylphenyl)-2-{4-[2-Hydroxy-3-(2-Methoxyphenoxy)propyl]piperazin-1-Yl}acetamide

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14524 (SCN5A_HUMAN)  -  Sodium channel protein type 5 subunit alpha
UniProt id: Q14524    2015 a.a.  
1. 4dck A     153 a.a. 153   X-ray 2.20 Å
  2. 4jq0 D     142 a.a. 142   X-ray 3.84 Å
  3. 2kbi A     97 a.a. 93   NMR  
  4. 2l53 B     31 a.a. 27   NMR  
  5. 4djc B     13 a.a. 11   X-ray 1.35 Å
There are no PDB entries containing ranolazine bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q15858 (SCN9A_HUMAN)  -  Sodium channel protein type 9 subunit alpha
UniProt id: Q15858    1988 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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