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DB00227 : lovastatin

Approved drug lovastatin ... 3 targets DB00227

Generic name: lovastatin PDB Het Group: 803
 
1 structure in PDB
Brand name(s): altocor, altoprev, artein, belvas, cholestra, closterol, colevix, hipolip, hipovastin, lestatin, lipdip, lipivas, lipofren, lovalip, lovalord, lovasterol, lovastin, lozutin, mevacor, mevinacor, mevlor, monacolin k, nergadan, paschol, rodatin, rovacor, sivlor, taucor, tecnolip, teroltrat.
Formula: C24H36O5
IUPAC Formula: (1s,3r,7s,8s,8ar)-8-{2-[(2r,4r)-4-Hydroxy-6-Oxooxan-2-Yl]ethyl}-3,7-Dimethyl-1,2,3,7,8,8a-
Hexahydronaphthalen-1-Yl (2s)-2-Methylbutanoate
PDB name: Lovastatin

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
Links  
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Target proteins

DrugBank drug Target 1:   UniProt id: P04035 (HMDH_HUMAN)  -  3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt id: P04035    887 a.a.  
1. 3cd5 A,B,C,D     425 a.a. 424   X-ray 2.39 Å
  2. 2q6b A,B,C,D     425 a.a. 423   X-ray 2.00 Å
  3. 3cda A,B,C     422 a.a. 421   X-ray 2.07 Å
  4. 2q6c A,B,C,D     421 a.a. 420   X-ray 2.00 Å
  5. 3ccw A,B,C     421 a.a. 420   X-ray 2.10 Å
   more ...
There are no PDB entries containing lovastatin bound to this target protein, although there are 22 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P20701 (ITAL_HUMAN)  -  Integrin alpha-L
UniProt id: P20701    1169 a.a.  
1cqp A,B   182 a.a. 181   X-ray 2.60 Å
The PDB contains 1 entry of lovastatin bound to this target protein and 32 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 3:   UniProt id: Q92769 (HDAC2_HUMAN)  -  Histone deacetylase 2
UniProt id: Q92769    487 a.a.  
1. 4ly1 A,B,C     368 a.a. 368   X-ray 1.57 Å
  2. 4lxz A,B,C     368 a.a. 368   X-ray 1.85 Å
  3. 3max A,B,C     367 a.a. 366   X-ray 2.05 Å
There are no PDB entries containing lovastatin bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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