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DB00203 : sildenafil

Approved drug sildenafil ... 3 targets DB00203

Generic name: sildenafil PDB Het Group: VIA
 
5 structures in PDB
Brand name(s): revatio, viagra.
Formula: C22H30N6O4S
IUPAC Formula: 5-[2-Ethoxy-5-(4-Methylpiperazine-1-Sulfonyl)phenyl]-1-Methyl-3-Propyl-1h,4h,7h-Pyrazolo[4,3-
D]pyrimidin-7-One
PDB name: 5-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-1-Methyl-3-Propyl-1h,6h,7h-Pyrazolo[4,3-
D]pyrimidin-7-One

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 4 
There are 4 PDB structures of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: O76074 (PDE5A_HUMAN)  -  CGMP-specific 3',5'-cyclic phosphodiesterase
UniProt id: O76074    874 a.a.  
1. 2h42 A,B,C   326 a.a. 326   X-ray 2.30 Å
  2. 1udt A   313 a.a. 313   X-ray 2.30 Å
  3. 1tbf A   326 a.a. 308   X-ray 1.30 Å
  4. 3jwq A,B,C,D   324 a.a. 302   X-ray 2.87 Å
The PDB contains 4 entries of sildenafil bound to this target protein and 33 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P18545 (CNRG_HUMAN)  -  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt id: P18545    87 a.a.  
   more ...
There are no PDB entries containing sildenafil bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: Q13956 (CNCG_HUMAN)  -  Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt id: Q13956    83 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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