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DB00200 : hydroxocobalamin

Approved drug hydroxocobalamin ... 9 targets DB00200

Generic name: hydroxocobalamin PDB Het Group: I2A
 
2 structures in PDB
Brand name(s): acti-b12, alpharedisol, cyanokit, hydro cobex, hydroxy cobal.
Formula: C62H89Con13O15P
IUPAC Formula: None
PDB name: Hydroxocobalamin

9
There are 9 target proteins defined in DrugBank for this drug.
 8 
8 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q99707 (METH_HUMAN)  -  Methionine synthase
UniProt id: Q99707    1264 a.a.  
1. 4ccz A     611 a.a. 611   X-ray 2.70 Å
  2. 2o2k A,B     332 a.a. 330   X-ray 1.60 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P22033 (MUTA_HUMAN)  -  Methylmalonyl-CoA mutase, mitochondrial
UniProt id: P22033    749 a.a.  
1. 3bic A,B     715 a.a. 713   X-ray 2.60 Å
  2. 2xiq A,B     714 a.a. 712   X-ray 1.95 Å
  3. 2xij A     710 a.a. 708   X-ray 1.95 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q9UBK8 (MTRR_HUMAN)  -  Methionine synthase reductase, mitochondrial
UniProt id: Q9UBK8    724 a.a.  
1. 2qtz A     445 a.a. 442   X-ray 1.90 Å
  2. 2qtl A     445 a.a. 441   X-ray 1.90 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q8IVH4 (MMAA_HUMAN)  -  Methylmalonic aciduria type A protein, mitochondrial
UniProt id: Q8IVH4    417 a.a.  
2www A     298 a.a. 298   X-ray 2.64 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: P20061 (TCO1_HUMAN)  -  Transcobalamin-1
UniProt id: P20061    432 a.a.  
1. 2ckv Y     410 a.a. 409   Theor. model
  2. 4kki A     398 a.a. 397   X-ray 2.35 Å
  3. 4kkj A     398 a.a. 397   X-ray 3.00 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: Q9BXJ7 (AMNLS_HUMAN)  -  Amnionless protein
UniProt id: Q9BXJ7    453 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: O60494 (CUBN_HUMAN)  -  Cubilin
UniProt id: O60494    3622 a.a.  
3kq4 B,D,F     457 a.a. 457   X-ray 3.30 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 8:   UniProt id: Q96EY8 (MMAB_HUMAN)  -  Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
UniProt id: Q96EY8    249 a.a.  
2idx A     148 a.a. 148   X-ray 2.50 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 9:   UniProt id: Q9Y4U1 (MMAC_HUMAN)  -  Methylmalonic aciduria and homocystinuria type C protein
UniProt id: Q9Y4U1    281 a.a.  
1. 3sc0 A     237 a.a. 237   X-ray 1.95 Å
  2. 3sbz A     234 a.a. 234   X-ray 2.00 Å
  3. 3som A,B,C,D,...     227 a.a. 227   X-ray 2.40 Å
  4. 3sby A,B     218 a.a. 213   X-ray 2.71 Å
There are no PDB entries containing hydroxocobalamin bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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