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DB00193 : tramadol

Approved drug tramadol ... 9 targets DB00193

Generic name: tramadol
 
Brand name(s): conzip, crispin, durela, ralivia er, ralivia flashtab, rybix, tramadol hcl bp/ep, tramal, tridural, ultram, ultram er, zytram xl.
Formula: C16H25No2
IUPAC Formula: (1r,2r)-2-[(Dimethylamino)methyl]-1-(3-Methoxyphenyl)cyclohexan-1-Ol

9
There are 9 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35372 (OPRM_HUMAN)  -  Mu-type opioid receptor
UniProt id: P35372    400 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P23975 (SC6A2_HUMAN)  -  Sodium-dependent noradrenaline transporter
UniProt id: P23975    617 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P31645 (SC6A4_HUMAN)  -  Sodium-dependent serotonin transporter
UniProt id: P31645    630 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P28335 (5HT2C_HUMAN)  -  5-hydroxytryptamine 2C receptor
UniProt id: P28335    458 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P41145 (OPRK_HUMAN)  -  Kappa-type opioid receptor
UniProt id: P41145    379 a.a.  
2a0d A     380 a.a. 378   Theor. model
There are no PDB entries containing tramadol bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P41143 (OPRD_HUMAN)  -  Delta-type opioid receptor
UniProt id: P41143    371 a.a.  
1ozc A     268 a.a. 268   Theor. model
There are no PDB entries containing tramadol bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: Q8TCU5 (NMD3A_HUMAN)  -  Glutamate [NMDA] receptor subunit 3A
UniProt id: Q8TCU5    1115 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: Q693P7 (Q693P7_HUMAN)  -  Alpha-7 nicotinic cholinergic receptor subunit
UniProt id: Q693P7    28 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing tramadol bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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