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DB00191 : phentermine

Approved drug phentermine ... 5 targets DB00191

Generic name: phentermine
 
Brand name(s): adipex-p, duromine, fastin, inoamin, ionamin, linyl, lipopill, lonamin, mirapront, normephentermine, obenix, obestin-30, oby-trim, omnibex, ona mast, ona-mast, phentercot, phentermine resin 30, phentride, pro-fast, suprenza, teramine, tora, uritone, wilpo, wyamine sulfate, zantryl.
Formula: C10H15N
IUPAC Formula: 2-Methyl-1-Phenylpropan-2-Amine

5
There are 5 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P23975 (SC6A2_HUMAN)  -  Sodium-dependent noradrenaline transporter
UniProt id: P23975    617 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P31645 (SC6A4_HUMAN)  -  Sodium-dependent serotonin transporter
UniProt id: P31645    630 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q01959 (SC6A3_HUMAN)  -  Sodium-dependent dopamine transporter
UniProt id: Q01959    620 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P21397 (AOFA_HUMAN)  -  Amine oxidase [flavin-containing] A
UniProt id: P21397    526 a.a.  
1. 2z5x A     513 a.a. 513   X-ray 2.20 Å
  2. 2z5y A     513 a.a. 512   X-ray 2.17 Å
  3. 2bxs A,B     490 a.a. 490   X-ray 3.15 Å
  4. 1h8q A     455 a.a. 455   Theor. model
  5. 2bxr A,B     445 a.a. 445   X-ray 3.00 Å
There are no PDB entries containing phentermine bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P27338 (AOFB_HUMAN)  -  Amine oxidase [flavin-containing] B
UniProt id: P27338    519 a.a.  
1. 1s3e A,B     499 a.a. 499   X-ray 1.60 Å
  2. 2v5z A,B     499 a.a. 499   X-ray 1.60 Å
  3. 2xfn A,B     499 a.a. 499   X-ray 1.60 Å
  4. 1s3b A,B     499 a.a. 499   X-ray 1.65 Å
  5. 2xfp A,B     499 a.a. 499   X-ray 1.66 Å
   more ...
There are no PDB entries containing phentermine bound to this target protein, although there are 41 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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