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DB00172 : l-proline

Approved nutraceutical l-proline ... 22 targets DB00172

Generic name: l-proline PDB Het Group: ZED
 
1 structure in PDB
Brand name(s): none.
Formula: C5H9No2
IUPAC Formula: (2s)-Pyrrolidine-2-Carboxylic acid
PDB name: L-Proline, 1-[(2s)-3-Mercapto-2-Methyl-1-Oxopropyl]-4-(Phenylthio)-, 4s

22
There are 22 target proteins defined in DrugBank for this nutraceutical.
 9 
9 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q13427 (PPIG_HUMAN)  -  Peptidyl-prolyl cis-trans isomerase G
UniProt id: Q13427    753 a.a.  
1. 2wfj A     172 a.a. 172   X-ray
  2. 2gw2 A     173 a.a. 171   X-ray 1.80 Å
  3. 2wfi A     171 a.a. 170   X-ray
There are no PDB entries containing l-proline bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 2:   UniProt id: Q32P28 (P3H1_HUMAN)  -  Prolyl 3-hydroxylase 1
UniProt id: Q32P28    736 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: Q4W8W1 (Q4W8W1_HUMAN)  -  Pyrroline 5-carboxylate reductase isoform
UniProt id: Q4W8W1    319 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: Q7L3T8 (SYPM_HUMAN)  -  Probable prolyl-tRNA synthetase, mitochondrial
UniProt id: Q7L3T8    475 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: Q8IVL5 (P3H2_HUMAN)  -  Prolyl 3-hydroxylase 2
UniProt id: Q8IVL5    708 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 6:   UniProt id: Q8IVL6 (P3H3_HUMAN)  -  Prolyl 3-hydroxylase 3
UniProt id: Q8IVL6    736 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: Q53H96 (P5CR3_HUMAN)  -  Pyrroline-5-carboxylate reductase 3
UniProt id: Q53H96    274 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 8:   UniProt id: Q96EM0 (T3HPD_HUMAN)  -  Chromosome 14 open reading frame 149
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: P32322 (P5CR1_HUMAN)  -  Pyrroline-5-carboxylate reductase 1
UniProt id: P32322    319 a.a.  
1. 2ger A,B,C,D,E     277 a.a. 275   X-ray 3.10 Å
  2. 2gr9 A,B,C,D,E     277 a.a. 275   X-ray 3.10 Å
  3. 2gra A,B,C,D,E     277 a.a. 275   X-ray 3.10 Å
  4. 2izz A,B,C,D,E     272 a.a. 271   X-ray 1.95 Å
There are no PDB entries containing l-proline bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 10:   UniProt id: P07814 (SYEP_HUMAN)  -  Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
UniProt id: P07814    1511 a.a.  
1. 4k87 A     490 a.a. 490   X-ray 2.30 Å
  2. 4k88 A     490 a.a. 490   X-ray 2.62 Å
  3. 4k86 A     488 a.a. 488   X-ray 2.40 Å
  4. 4hvc A,B     482 a.a. 482   X-ray 2.00 Å
  5. 1fyj A     57 a.a. 57   NMR  
There are no PDB entries containing l-proline bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 11:   UniProt id: O15460 (P4HA2_HUMAN)  -  Prolyl 4-hydroxylase subunit alpha-2
UniProt id: O15460    535 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 12:   UniProt id: Q9UN76 (S6A14_HUMAN)  -  Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
UniProt id: Q9UN76    642 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 13:   UniProt id: Q99884 (SC6A7_HUMAN)  -  Sodium-dependent proline transporter
UniProt id: Q99884    636 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 14:   UniProt id: Q96C36 (P5CR2_HUMAN)  -  Pyrroline-5-carboxylate reductase 2
UniProt id: Q96C36    320 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 15:   UniProt id: O43272 (PROD_HUMAN)  -  Proline oxidase, mitochondrial
UniProt id: O43272    600 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 16:   UniProt id: O43447 (PPIH_HUMAN)  -  Peptidyl-prolyl cis-trans isomerase H
UniProt id: O43447    176 a.a.  
1. 1mzw A     173 a.a. 173   X-ray 2.00 Å
  2. 1qoi A     173 a.a. 173   X-ray 2.00 Å
There are no PDB entries containing l-proline bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 17:   UniProt id: O94903 (PROSC_HUMAN)  -  Proline synthetase co-transcribed bacterial homolog protein
UniProt id: O94903    275 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 18:   UniProt id: P13674 (P4HA1_HUMAN)  -  Prolyl 4-hydroxylase subunit alpha-1
UniProt id: P13674    533 a.a.  
1. 4bta A     237 a.a. 237   X-ray 2.95 Å
  2. 4bt9 A,B     236 a.a. 236   X-ray 1.90 Å
  3. 4btb A     231 a.a. 231   X-ray 1.90 Å
  4. 2yq8 A,B     225 a.a. 225   X-ray 2.99 Å
  5. 4bt8 A,B     222 a.a. 222   X-ray 2.20 Å
   more ...
There are no PDB entries containing l-proline bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 19:   UniProt id: P23284 (PPIB_HUMAN)  -  Peptidyl-prolyl cis-trans isomerase B
UniProt id: P23284    215 a.a.  
1. 3ici A,B     187 a.a. 184   X-ray 1.70 Å
  2. 3ich A     180 a.a. 180   X-ray 1.20 Å
  3. 1cyn A     178 a.a. 178   X-ray 1.85 Å
There are no PDB entries containing l-proline bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 20:   UniProt id: P30405 (PPIF_HUMAN)  -  Peptidyl-prolyl cis-trans isomerase, mitochondrial
UniProt id: P30405    206 a.a.  
1. 4o8h A     164 a.a. 163   X-ray
  2. 2z6w A,B     164 a.a. 163   X-ray
  3. 3rcg A     164 a.a. 163   X-ray
  4. 4j5e X     164 a.a. 163   X-ray
  5. 4j5c X     164 a.a. 163   X-ray 1.03 Å
   more ...
There are no PDB entries containing l-proline bound to this target protein, although there are 28 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 21:   UniProt id: P45877 (PPIC_HUMAN)  -  Peptidyl-prolyl cis-trans isomerase C
UniProt id: P45877    211 a.a.  
2esl A,B,C,D,...     181 a.a. 181   X-ray 1.90 Å
There are no PDB entries containing l-proline bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 22:   UniProt id: P62937 (PPIA_HUMAN)  -  Peptidyl-prolyl cis-trans isomerase A
UniProt id: P62937    164 a.a.  
1. 3k0m A     164 a.a. 164   X-ray 1.25 Å
  2. 1awq A     164 a.a. 164   X-ray 1.58 Å
  3. 1awr A,B,C,D,...     164 a.a. 164   X-ray 1.58 Å
  4. 1ynd A,B     164 a.a. 164   X-ray 1.60 Å
  5. 2cpl A     164 a.a. 164   X-ray 1.63 Å
   more ...
There are no PDB entries containing l-proline bound to this target protein, although there are 63 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with l-proline bound in the PDB

There is 1 "non-target" protein in the PDB containing the l-proline molecule bound. That is, the UniProt code for the protein is missing or does not match any of the nutraceutical targets listed above.

Protein 1:   UniProt id: P00727 ()  -  Cytosol aminopeptidase OS=Bos taurus GN=LAP3 PE=1 SV=3
UniProt id: P00727    518 a.a.  
2ewb A   486 a.a. 486   X-ray 1.85 Å
The PDB contains 1 entry of l-proline bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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