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DB00168 : aspartame

Approved nutraceutical aspartame ... 2 targets DB00168

Generic name: aspartame PDB Het Group: PME
 
2 structures in PDB
Brand name(s): aminosweet, canderel, equal, nutrasweet, tri-sweet.
Formula: C14H18N2O5
IUPAC Formula: (3s)-3-Amino-3-{[(2s)-1-Methoxy-1-Oxo-3-Phenylpropan-2-Yl]carbamoyl}propanoic acid
PDB name: N-L-Alpha-Aspartyl l-Phenylalanine 1-Methyl ester

2
There are 2 target proteins defined in DrugBank for this nutraceutical.
 2 
There are 2 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q8NER1 (TRPV1_HUMAN)  -  Transient receptor potential cation channel subfamily V member 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: Q8TE23 (TS1R2_HUMAN)  -  Taste receptor type 1 member 2
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:  

 

Other proteins with aspartame bound in the PDB

There are 2 "non-target" proteins in the PDB containing the aspartame molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above.

Protein 1:   UniProt id: B7T1D7 ()  -  Teg12 OS=uncultured soil bacterium GN=teg12 PE=1 SV=1
UniProt id: B7T1D7    285 a.a.  
3mgc A   255 a.a. 232   X-ray 2.91 Å
The PDB contains 1 entry of aspartame bound to this protein
Protein 2:   UniProt id: P01709 ()  -  Ig lambda chain V-II region MGC OS=Homo sapiens PE=1 SV=1
UniProt id: P01709    110 a.a.  
1a8j L,H   215 a.a. 110   X-ray 2.70 Å
The PDB contains 1 entry of aspartame bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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