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DB00167 : l-isoleucine

Approved nutraceutical l-isoleucine ... 6 targets DB00167

Generic name: l-isoleucine PDB Het Group: 28J
 
Brand name(s): none.
Formula: C6H13No2
IUPAC Formula: (2s,3s)-2-Amino-3-Methylpentanoic acid
PDB name: D-Alloisoleucine

6
There are 6 target proteins defined in DrugBank for this nutraceutical.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q5TCD1 (Q5TCD1_HUMAN)  -  Isoleucine-tRNA synthetase
UniProt id: Q5TCD1    330 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: Q9NSE4 (SYIM_HUMAN)  -  Isoleucyl-tRNA synthetase, mitochondrial
UniProt id: Q9NSE4    1012 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: P45954 (ACDSB_HUMAN)  -  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt id: P45954    431 a.a.  
2jif A,B,C,D     381 a.a. 381   X-ray 2.00 Å
There are no PDB entries containing l-isoleucine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 4:   UniProt id: P54687 (BCAT1_HUMAN)  -  Branched-chain-amino-acid aminotransferase, cytosolic
UniProt id: P54687    385 a.a.  
1. 2abj A,D,G,J     366 a.a. 362   X-ray 2.20 Å
  2. 2coj A,B     359 a.a. 358   X-ray 2.40 Å
  3. 2coi A,B     358 a.a. 357   X-ray 1.90 Å
  4. 2cog A,B     358 a.a. 357   X-ray 2.10 Å
There are no PDB entries containing l-isoleucine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 5:   UniProt id: O15382 (BCAT2_HUMAN)  -  Branched-chain-amino-acid aminotransferase, mitochondrial
UniProt id: O15382    391 a.a.  
1. 1kta A,B     365 a.a. 364   X-ray 1.90 Å
  2. 1ekf A,B     365 a.a. 364   X-ray 1.95 Å
  3. 1ekv A,B     365 a.a. 364   X-ray 2.25 Å
  4. 1ekp A,B     365 a.a. 364   X-ray 2.50 Å
  5. 2a1h A,B     363 a.a. 362   X-ray 1.80 Å
   more ...
There are no PDB entries containing l-isoleucine bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 6:   UniProt id: P41252 (SYIC_HUMAN)  -  Isoleucyl-tRNA synthetase, cytoplasmic
UniProt id: P41252    1262 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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