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DB00160 : l-alanine

Approved nutraceutical l-alanine ... 13 targets DB00160

Generic name: l-alanine PDB Het Group: ALA
 
38 structures in PDB
Brand name(s): none.
Formula: C3H7No2
IUPAC Formula: (2s)-2-Aminopropanoic acid
PDB name: Alanine

13
There are 13 target proteins defined in DrugBank for this nutraceutical.
 3 
3 of these target proteins have one or more structures in the PDB.
 30 
There are 30 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q9UHI5 (LAT2_HUMAN)  -  Large neutral amino acids transporter small subunit 2
UniProt id: Q9UHI5    535 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: Q9BYV1 (AGT2_HUMAN)  -  Alanine--glyoxylate aminotransferase 2, mitochondrial
UniProt id: Q9BYV1    514 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: P49588 (SYAC_HUMAN)  -  Alanyl-tRNA synthetase, cytoplasmic
UniProt id: P49588    968 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: P43007 (SATT_HUMAN)  -  Neutral amino acid transporter A
UniProt id: P43007    532 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: P21549 (SPYA_HUMAN)  -  Serine--pyruvate aminotransferase
UniProt id: P21549    391 a.a.  
1. 3imz A,C     387 a.a. 387   X-ray 2.35 Å
  2. 4kyo A,C     387 a.a. 386   X-ray 2.20 Å
  3. 1h0c A     386 a.a. 386   X-ray 2.50 Å
  4. 3r9a A,C     386 a.a. 385   X-ray 2.35 Å
  5. 4kxk A,C     387 a.a. 385   X-ray 2.90 Å
   more ...
There are no PDB entries containing l-alanine bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 6:   UniProt id: P80404 (GABT_HUMAN)  -  4-aminobutyrate aminotransferase, mitochondrial
UniProt id: P80404    500 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: Q16719 (KYNU_HUMAN)  -  Kynureninase
UniProt id: Q16719    464 a.a.  
1. 2hzp A     446 a.a. 445   X-ray 2.00 Å
  2. 3e9k A     445 a.a. 444   X-ray 1.70 Å
There are no PDB entries containing l-alanine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 8:   UniProt id: Q5JTZ9 (SYAM_HUMAN)  -  Probable alanyl-tRNA synthetase, mitochondrial
UniProt id: Q5JTZ9    985 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: Q8IUZ5 (AT2L2_HUMAN)  -  Alanine--glyoxylate aminotransferase 2-like 2
UniProt id: Q8IUZ5    450 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 10:   UniProt id: Q8TD30 (ALAT2_HUMAN)  -  Alanine aminotransferase 2
UniProt id: Q8TD30    522 a.a.  
3ihj A     461 a.a. 454   X-ray 2.30 Å
There are no PDB entries containing l-alanine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 11:   UniProt id: P24298 (ALAT1_HUMAN)  -  Alanine aminotransferase 1
UniProt id: P24298    496 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 12:   UniProt id: Q9Y697 (NFS1_HUMAN)  -  Cysteine desulfurase, mitochondrial
UniProt id: Q9Y697    457 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 13:   UniProt id: Q7Z2H8 (S36A1_HUMAN)  -  Proton-coupled amino acid transporter 1
UniProt id: Q7Z2H8    476 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with l-alanine bound in the PDB

There are 25 "non-target" proteins in the PDB containing the l-alanine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above. Only 10 of the 25 proteins are listed below.

Protein 1:   UniProt id: A0MK70 ()  -  Fiber-1 OS=Human adenovirus 52 PE=4 SV=1
UniProt id: A0MK70    362 a.a.  
4xl8 B   161 a.a. 161   X-ray 1.65 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 2:   UniProt id: A9CL58 ()  -  Putative UDP-glucose 4-epimerase OS=Agrobacterium tumefaciens (strain C58 / ATCC 33970) GN=galE PE=1 SV=1
UniProt id: A9CL58    326 a.a.  
4id9 A,B   321 a.a. 320   X-ray 1.60 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 3:   UniProt id: B7CIR9 ()  -  Branched-chain-amino-acid transaminase OS=Burkholderia pseudomallei 576 GN=ilvE PE=1 SV=1
UniProt id: B7CIR9    306 a.a.  
4whx A,B,C,D,...   305 a.a. 304   X-ray 2.05 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 4:   UniProt id: D3T7F1 ()  -  Biotin and thiamin synthesis associated OS=Thermoanaerobacter italicus (strain DSM 9252 / Ab9) GN=Thit_0582 PE=4 SV=1
UniProt id: D3T7F1    465 a.a.  
4wcx A,C   454 a.a. 454   X-ray 1.59 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 5:   UniProt id: E9P5T5 ()  -  Glutamate receptor 1 OS=Adineta vaga PE=1 SV=1
UniProt id: E9P5T5    894 a.a.  
4io5 A,B   242 a.a. 240   X-ray 1.72 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 6:   UniProt id: F0QP95 ()  -  Peptidoglycan-associated lipoprotein OS=Acinetobacter baumannii (strain TCDC-AB0715) GN=pal PE=1 SV=1
UniProt id: F0QP95    190 a.a.  
4g4w A   108 a.a. 108   X-ray 1.90 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 7:   UniProt id: O67323 ()  -  Alanine--tRNA ligase OS=Aquifex aeolicus (strain VF5) GN=alaS PE=1 SV=1
UniProt id: O67323    866 a.a.  
1yfs A,B   448 a.a. 444   X-ray 2.08 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 8:   UniProt id: O75164 ()  -  Lysine-specific demethylase 4A OS=Homo sapiens GN=KDM4A PE=1 SV=2
UniProt id: O75164    1063 a.a.  
4v2v A,B   353 a.a. 353   X-ray 2.00 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 9:   UniProt id: P00772 ()  -  Chymotrypsin-like elastase family member 1 OS=Sus scrofa GN=CELA1 PE=1 SV=1
UniProt id: P00772    265 a.a.  
2bd3 A   240 a.a. 239   X-ray 1.60 Å
The PDB contains 1 entry of l-alanine bound to this protein
Protein 10:   UniProt id: P11974 ()  -  Pyruvate kinase PKM OS=Oryctolagus cuniculus GN=PKM PE=1 SV=4
UniProt id: P11974    530 a.a.  
2g50 A,B,C,D,...   519 a.a. 516   X-ray 1.65 Å
The PDB contains 1 entry of l-alanine bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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