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DB00154 : gamma-homolinolenic acid

Approved nutraceutical gamma-homolinolenic acid ... 2 targets DB00154

Generic name: gamma-homolinolenic acid PDB Het Group: LAX
 
1 structure in PDB
Brand name(s): star gla (gnc), tona-lean 1000 cla (action labs).
Formula: C20H34O2
IUPAC Formula: (8z,11z,14z)-Icosa-8,11,14-Trienoic acid
PDB name: Eicosa-8,11,14-Trienoic acid

2
There are 2 target proteins defined in DrugBank for this nutraceutical.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing gamma-homolinolenic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with gamma-homolinolenic acid bound in the PDB

There is 1 "non-target" protein in the PDB containing the gamma-homolinolenic acid molecule bound. That is, the UniProt code for the protein is missing or does not match any of the nutraceutical targets listed above.

Protein 1:   UniProt id: P05979 ()  -  Prostaglandin G/H synthase 1 OS=Ovis aries GN=PTGS1 PE=1 SV=2
UniProt id: P05979    599 a.a.  
1fe2 A   553 a.a. 552   X-ray 3.00 Å
The PDB contains 1 entry of gamma-homolinolenic acid bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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