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DB00151 : l-cysteine

Approved nutraceutical l-cysteine ... 14 targets DB00151

Generic name: l-cysteine PDB Het Group: CYS
 
67 structures in PDB
Brand name(s): none.
Formula: C3H7No2S
IUPAC Formula: (2r)-2-Amino-3-Sulfanylpropanoic acid
PDB name: Cysteine

14
There are 14 target proteins defined in DrugBank for this nutraceutical.
 7 
7 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the nutraceutical molecule bound to its target protein.
 54 
There are 54 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q9BZV2 (S19A3_HUMAN)  -  Thiamine transporter 2
UniProt id: Q9BZV2    496 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: Q9HA77 (SYCM_HUMAN)  -  Probable cysteinyl-tRNA synthetase, mitochondrial
UniProt id: Q9HA77    564 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: Q9Y600 (CSAD_HUMAN)  -  Cysteine sulfinic acid decarboxylase
UniProt id: Q9Y600    492 a.a.  
2jis A,B     478 a.a. 478   X-ray 1.60 Å
There are no PDB entries containing l-cysteine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 4:   UniProt id: Q9Y697 (NFS1_HUMAN)  -  Cysteine desulfurase, mitochondrial
UniProt id: Q9Y697    457 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: Q16878 (CDO1_HUMAN)  -  Cysteine dioxygenase type 1
UniProt id: Q16878    199 a.a.  
2ic1 A   185 a.a. 185   X-ray 2.70 Å
The PDB contains 1 entry of l-cysteine bound to this target protein
DrugBank nutraceutical Target 6:   UniProt id: P48507 (GSH0_HUMAN)  -  Glutamate--cysteine ligase regulatory subunit
UniProt id: P48507    274 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: P48506 (GSH1_HUMAN)  -  Glutamate--cysteine ligase catalytic subunit
UniProt id: P48506    637 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 8:   UniProt id: Q16857 (Q16857_HUMAN)  -  Cysteine dioxygenase
UniProt id: Q16857    56 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: P17174 (AATC_HUMAN)  -  Aspartate aminotransferase, cytoplasmic
UniProt id: P17174    412 a.a.  
3ii0 A,B,C,D     405 a.a. 398   X-ray 2.05 Å
There are no PDB entries containing l-cysteine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 10:   UniProt id: P32929 (CGL_HUMAN)  -  Cystathionine gamma-lyase
UniProt id: P32929    404 a.a.  
1. 3cog A,B,C,D     376 a.a. 376   X-ray 2.00 Å
  2. 2nmp A,B,C,D     376 a.a. 376   X-ray 2.60 Å
  3. 3elp B,A,C,D     343 a.a. 343   X-ray 2.40 Å
There are no PDB entries containing l-cysteine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 11:   UniProt id: P35520 (CBS_HUMAN)  -  Cystathionine beta-synthase
UniProt id: P35520    550 a.a.  
1. 4l3v B,A,C     498 a.a. 498   X-ray 3.63 Å
  2. 4l0d A,B     496 a.a. 496   X-ray 2.97 Å
  3. 4coo A,B     493 a.a. 493   X-ray 2.00 Å
  4. 4l28 A,B,C,D     493 a.a. 492   X-ray 2.63 Å
  5. 4l27 B,D,A,C     490 a.a. 489   X-ray 3.39 Å
   more ...
There are no PDB entries containing l-cysteine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 12:   UniProt id: P49589 (SYCC_HUMAN)  -  Cysteinyl-tRNA synthetase, cytoplasmic
UniProt id: P49589    748 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 13:   UniProt id: P16455 (MGMT_HUMAN)  -  Methylated-DNA--protein-cysteine methyltransferase
UniProt id: P16455    206 a.a.  
1. 1eh6 A     168 a.a. 168   X-ray 2.00 Å
  2. 1qnt A     166 a.a. 166   X-ray 1.90 Å
  3. 1yfh A,B     165 a.a. 165   X-ray 3.01 Å
  4. 1eh8 A     165 a.a. 164   X-ray 2.50 Å
  5. 1eh7 A     161 a.a. 160   X-ray 2.00 Å
   more ...
There are no PDB entries containing l-cysteine bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 14:   UniProt id: P48637 (GSHB_HUMAN)  -  Glutathione synthetase
UniProt id: P48637    473 a.a.  
2hgs A     472 a.a. 472   X-ray 2.10 Å
There are no PDB entries containing l-cysteine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with l-cysteine bound in the PDB

There are 42 "non-target" proteins in the PDB containing the l-cysteine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above. Only 10 of the 42 proteins are listed below.

Protein 1:   UniProt id: P00441 ()  -  Superoxide dismutase [Cu-Zn] OS=Homo sapiens GN=SOD1 PE=1 SV=2
UniProt id: P00441    153 a.a.  
4ff9 A,B   153 a.a. 153   X-ray 2.50 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 2:   UniProt id: P00784 ()  -  Papain OS=Carica papaya PE=1 SV=1
UniProt id: P00784    344 a.a.  
2pad A   212 a.a. 209   X-ray 2.80 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 3:   UniProt id: P00889 ()  -  Citrate synthase, mitochondrial OS=Sus scrofa GN=CS PE=1 SV=2
UniProt id: P00889    463 a.a.  
3enj A   437 a.a. 437   X-ray 1.78 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 4:   UniProt id: P01892 ()  -  HLA class I histocompatibility antigen, A-2 alpha chain OS=Homo sapiens GN=HLA-A PE=1 SV=1
UniProt id: P01892    364 a.a.  
3mre A   274 a.a. 273   X-ray 1.10 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 5:   UniProt id: P01901 ()  -  H-2 class I histocompatibility antigen, K-B alpha chain OS=Mus musculus GN=H2-K1 PE=1 SV=1
UniProt id: P01901    368 a.a.  
2zsv A,C   274 a.a. 274   X-ray 1.80 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 6:   UniProt id: P07013 ()  -  Primosomal replication protein n OS=Escherichia coli (strain K12) GN=priB PE=1 SV=3
UniProt id: P07013    104 a.a.  
1v1q A,B   111 a.a. 103   X-ray 2.10 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 7:   UniProt id: P07603 ()  -  Periplasmic [Fe] hydrogenase small subunit OS=Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) GN=hydB PE=1 SV=1
UniProt id: P07603    122 a.a.  
1hfe S,T   88 a.a. 88   X-ray 1.60 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 8:   UniProt id: P08185 ()  -  Corticosteroid-binding globulin OS=Homo sapiens GN=SERPINA6 PE=1 SV=1
UniProt id: P08185    404 a.a.  
4bb2 A   332 a.a. 331   X-ray 2.48 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 9:   UniProt id: P08887 ()  -  Interleukin-6 receptor subunit alpha OS=Homo sapiens GN=IL6R PE=1 SV=1
UniProt id: P08887    467 a.a.  
1n26 A   299 a.a. 299   X-ray 2.40 Å
The PDB contains 1 entry of l-cysteine bound to this protein
Protein 10:   UniProt id: P0A6W9 ()  -  Glutamate--cysteine ligase OS=Escherichia coli (strain K12) GN=gshA PE=1 SV=1
UniProt id: P0A6W9    517 a.a.  
1. 2d32 A,B,C,D   510 a.a. 506   X-ray 2.40 Å
  2. 2d33 A,B,C,D   510 a.a. 506   X-ray 2.60 Å
The PDB contains 2 entries of l-cysteine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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