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DB00150 : l-tryptophan

Approved nutraceutical l-tryptophan ... 3 targets DB00150

Generic name: l-tryptophan PDB Het Group: TRP
 
89 structures in PDB
Brand name(s): alti-tryptophan, lyphan.
Formula: C11H12N2O2
IUPAC Formula: (2s)-2-Amino-3-(1h-Indol-3-Yl)propanoic acid
PDB name: Tryptophan

3
There are 3 target proteins defined in DrugBank for this nutraceutical.
 2 
2 of these target proteins have one or more structures in the PDB.
 8 
There are 8 PDB structures of the nutraceutical molecule bound to its target protein.
 71 
There are 71 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q9UGM6 (SYWM_HUMAN)  -  Tryptophanyl-tRNA synthetase, mitochondrial
UniProt id: Q9UGM6    360 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: P00953 (SYW_GEOSE)  -  Tryptophanyl-tRNA synthetase
UniProt id: P00953    327 a.a.  
1. 1mb2 A,B,C,D,...   326 a.a. 324   X-ray 2.70 Å
  2. 3fhj A,D,B,E,F   299 a.a. 297   X-ray 2.65 Å
  3. 3fi0 A,B,C,D,...   297 a.a. 295   X-ray 2.70 Å
The PDB contains 4 entries of l-tryptophan bound to this target protein and 11 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 3:   UniProt id: P23381 (SYWC_HUMAN)  -  Tryptophanyl-tRNA synthetase, cytoplasmic
UniProt id: P23381    470 a.a.  
1. 2azx A,B   387 a.a. 385   X-ray 2.80 Å
  2. 2quh A,B   379 a.a. 375   X-ray 2.40 Å
  3. 2dr2 A   373 a.a. 373   X-ray 3.00 Å
  4. 2ake A   373 a.a. 373   X-ray 3.10 Å
The PDB contains 4 entries of l-tryptophan bound to this target protein and 11 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with l-tryptophan bound in the PDB

There are 35 "non-target" proteins in the PDB containing the l-tryptophan molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above. Only 10 of the 35 proteins are listed below.

Protein 1:   UniProt id: A4D0H5 ()  -  Tryptophan 5-halogenase OS=Streptomyces rugosporus GN=pyrH PE=1 SV=1
UniProt id: A4D0H5    510 a.a.  
2weu A,B,C,D   494 a.a. 493   X-ray 1.70 Å
The PDB contains 1 entry of l-tryptophan bound to this protein
Protein 2:   UniProt id: A5A665 ()  -  Transcription attenuation protein MtrB OS=Bacillus licheniformis (strain DSM 13 / ATCC 14580) GN=mtrB PE=1 SV=1
UniProt id: A5A665    75 a.a.  
3zte A,B,C,D,...   69 a.a. 69   X-ray 2.41 Å
The PDB contains 1 entry of l-tryptophan bound to this protein
Protein 3:   UniProt id: O53512 ()  -  Phospho-2-dehydro-3-deoxyheptonate aldolase AroG OS=Mycobacterium tuberculosis GN=aroG PE=1 SV=1
UniProt id: O53512    461 a.a.  
1. 2ypq A,B   460 a.a. 459   X-ray 2.76 Å
  2. 3rzi A,B   453 a.a. 453   X-ray 1.95 Å
  3. 3kgf A,B   452 a.a. 452   X-ray 2.00 Å
  4. 3nue A,B   453 a.a. 450   X-ray 2.50 Å
The PDB contains 4 entries of l-tryptophan bound to this protein
Protein 4:   UniProt id: O96771 ()  -  Tryptophan--tRNA ligase OS=Encephalitozoon cuniculi (strain GB-M1) GN=ECU11_0530 PE=1 SV=2
UniProt id: O96771    384 a.a.  
3tze A   360 a.a. 359   X-ray 2.60 Å
The PDB contains 1 entry of l-tryptophan bound to this protein
Protein 5:   UniProt id: P00897 ()  -  Anthranilate synthase component 1 OS=Serratia marcescens GN=trpE PE=1 SV=2
UniProt id: P00897    518 a.a.  
1i7s A,C   511 a.a. 503   X-ray 2.40 Å
The PDB contains 1 entry of l-tryptophan bound to this protein
Protein 6:   UniProt id: P00898 ()  -  Anthranilate synthase component 1 OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=trpE PE=1 SV=3
UniProt id: P00898    519 a.a.  
1i1q A   512 a.a. 511   X-ray 1.90 Å
The PDB contains 1 entry of l-tryptophan bound to this protein
Protein 7:   UniProt id: P04825 ()  -  Aminopeptidase N OS=Escherichia coli (strain K12) GN=pepN PE=1 SV=2
UniProt id: P04825    869 a.a.  
3b3b A   866 a.a. 866   X-ray 1.85 Å
The PDB contains 1 entry of l-tryptophan bound to this protein
Protein 8:   UniProt id: P05041 ()  -  Aminodeoxychorismate synthase component 1 OS=Escherichia coli (strain K12) GN=pabB PE=1 SV=1
UniProt id: P05041    452 a.a.  
1. 1k0e A   437 a.a. 437   X-ray 2.00 Å
  2. 1k0g A,B   420 a.a. 419   X-ray 2.05 Å
The PDB contains 2 entries of l-tryptophan bound to this protein
Protein 9:   UniProt id: P0A881 ()  -  Trp operon repressor OS=Escherichia coli (strain K12) GN=trpR PE=1 SV=2
UniProt id: P0A881    107 a.a.  
1. 1co0 A,B   105 a.a. 105   NMR  
  2. 2oz9 R   104 a.a. 104   X-ray 1.65 Å
  3. 2wrp R   104 a.a. 104   X-ray 1.65 Å
  4. 1trr A,B,D,E,...   105 a.a. 104   X-ray 2.40 Å
  5. 1rcs A,B   104 a.a. 104   NMR  
 
The PDB contains 10 entries of l-tryptophan bound to this protein
Protein 10:   UniProt id: P19466 ()  -  Transcription attenuation protein MtrB OS=Bacillus subtilis (strain 168) GN=mtrB PE=1 SV=1
UniProt id: P19466    74 a.a.  
1. 1wap A,B,C,D,...   68 a.a. 68   X-ray 1.80 Å
  2. 3zzq A,B,C,D,...   65 a.a. 65   X-ray 1.75 Å
  3. 4b27 A,B,C,D,...   64 a.a. 64   X-ray 2.72 Å
The PDB contains 3 entries of l-tryptophan bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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