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DB00143 : glutathione

Approved nutraceutical glutathione ... 40 targets DB00143

Generic name: glutathione PDB Het Group: GSH
 
263 structures in PDB
Brand name(s): copren, isethion, ledac, neuthion, tathion.
Formula: C10H17N3O6S
IUPAC Formula: (2s)-2-Amino-4-{[(1r)-1-[(Carboxymethyl)carbamoyl]-2-Sulfanylethyl]carbamoyl}butanoic acid
PDB name: Glutathione

40
There are 40 target proteins defined in DrugBank for this nutraceutical.
 32 
32 of these target proteins have one or more structures in the PDB.
 80 
There are 80 PDB structures of the nutraceutical molecule bound to its target protein.
 184 
There are 184 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P35754 (GLRX1_HUMAN)  -  Glutaredoxin-1
UniProt id: P35754    105 a.a.  
1b4q A   105 a.a. 101   NMR  
The PDB contains 1 entry of glutathione bound to this target protein and 2 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 2:   UniProt id: P36969 (GPX4_HUMAN)  -  Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
UniProt id: P36969    195 a.a.  
1. 2obi A     165 a.a. 164   X-ray 1.55 Å
  2. 2gs3 A     171 a.a. 162   X-ray 1.90 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 3:   UniProt id: P46439 (GSTM5_HUMAN)  -  Glutathione S-transferase Mu 5
UniProt id: P46439    218 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: P59796 (GPX6_HUMAN)  -  Glutathione peroxidase 6
UniProt id: P59796    221 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: Q16775 (GLO2_HUMAN)  -  Hydroxyacylglutathione hydrolase
UniProt id: Q16775    307 a.a.  
1qh5 A,B   260 a.a. 260   X-ray 1.45 Å
The PDB contains 1 entry of glutathione bound to this target protein and 3 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 6:   UniProt id: Q6NSD4 (Q6NSD4_HUMAN)  -  Hypothetical protein
UniProt id: Q6NSD4    145 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: Q6PI42 (Q6PI42_HUMAN)  -  Glutathione peroxidase 4
UniProt id: Q6PI42    197 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 8:   UniProt id: Q8TED1 (GPX8_HUMAN)  -  CDNA FLJ23636 fis, clone CAS07176
UniProt id: Q8TED1    208 a.a.  
1. 3kij A,B,C     171 a.a. 170   X-ray 1.80 Å
  2. 3cyn A,B,C     174 a.a. 165   X-ray 2.00 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 9:   UniProt id: Q96SL4 (GPX7_HUMAN)  -  Glutathione peroxidase 7
UniProt id: Q96SL4    186 a.a.  
2p31 A,B     155 a.a. 155   X-ray 2.00 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 10:   UniProt id: Q99735 (MGST2_HUMAN)  -  Microsomal glutathione S-transferase 2
UniProt id: Q99735    147 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 11:   UniProt id: O14880 (MGST3_HUMAN)  -  Microsomal glutathione S-transferase 3
UniProt id: O14880    152 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 12:   UniProt id: Q9H4Y5 (GSTO2_HUMAN)  -  Glutathione transferase omega-2
UniProt id: Q9H4Y5    242 a.a.  
1. 3qag A   238 a.a. 232   X-ray 2.00 Å
  2. 3q19 A,B   224 a.a. 218   X-ray 1.90 Å
The PDB contains 2 entries of glutathione bound to this target protein and 3 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 13:   UniProt id: Q9NS18 (GLRX2_HUMAN)  -  Glutaredoxin-2, mitochondrial
UniProt id: Q9NS18    163 a.a.  
1. 2ht9 A   104 a.a. 104   X-ray 1.90 Å
  2. 2fls A   101 a.a. 100   X-ray 2.05 Å
The PDB contains 3 entries of glutathione bound to this target protein
DrugBank nutraceutical Target 14:   UniProt id: Q04760 (LGUL_HUMAN)  -  Lactoylglutathione lyase
UniProt id: Q04760    183 a.a.  
1. 3w0t A,B,C,D     176 a.a. 176   X-ray 1.35 Å
  2. 3vw9 A,B     176 a.a. 176   X-ray 1.47 Å
  3. 1qip A,B,C,D     176 a.a. 176   X-ray 1.72 Å
  4. 1qin A,B     176 a.a. 176   X-ray 2.00 Å
  5. 1fro A,B,C,D     176 a.a. 176   X-ray 2.20 Å
   more ...
There are no PDB entries containing glutathione bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 15:   UniProt id: Q16873 (LTC4S_HUMAN)  -  Leukotriene C4 synthase
UniProt id: Q16873    149 a.a.  
1. 2pno A,B,C,D,...   146 a.a. 146   X-ray 3.30 Å
  2. 3pcv A   146 a.a. 145   X-ray 1.90 Å
  3. 2uuh A   151 a.a. 145   X-ray 2.15 Å
  4. 3leo A   150 a.a. 143   X-ray 2.10 Å
  5. 3b29 A   142 a.a. 142   X-ray 3.20 Å
The PDB contains 5 entries of glutathione bound to this target protein and 12 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 16:   UniProt id: P00390 (GSHR_HUMAN)  -  Glutathione reductase, mitochondrial
UniProt id: P00390    521 a.a.  
1. 3dk8 A   462 a.a. 462   X-ray 1.10 Å
  2. 3dk4 A   462 a.a. 462   X-ray 1.20 Å
  3. 1gra A   461 a.a. 461   X-ray 2.00 Å
  4. 1gre A   461 a.a. 461   X-ray 2.00 Å
  5. 1dnc A   460 a.a. 459   X-ray 1.70 Å
The PDB contains 6 entries of glutathione bound to this target protein and 27 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 17:   UniProt id: P48637 (GSHB_HUMAN)  -  Glutathione synthetase
UniProt id: P48637    473 a.a.  
2hgs A   472 a.a. 472   X-ray 2.10 Å
The PDB contains 1 entry of glutathione bound to this target protein
DrugBank nutraceutical Target 18:   UniProt id: P09488 (GSTM1_HUMAN)  -  Glutathione S-transferase Mu 1
UniProt id: P09488    217 a.a.  
1. 1xw6 A,B,C,D   217 a.a. 217   X-ray 1.90 Å
  2. 1yj6 A,B,C   217 a.a. 217   X-ray 2.50 Å
The PDB contains 2 entries of glutathione bound to this target protein and 5 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 19:   UniProt id: Q9Y2Q3 (GSTK1_HUMAN)  -  Glutathione S-transferase kappa 1
UniProt id: Q9Y2Q3    225 a.a.  
1. 3rpn A,B,C,D,...     220 a.a. 220   X-ray 1.90 Å
  2. 1yzx A,B     218 a.a. 218   X-ray 1.93 Å
  3. 3rpp A,B,C     216 a.a. 216   X-ray 1.80 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 20:   UniProt id: Q16772 (GSTA3_HUMAN)  -  Glutathione S-transferase A3
UniProt id: Q16772    221 a.a.  
1. 2vcv A,B,C,D,...   219 a.a. 219   X-ray 1.80 Å
  2. 1tdi A,B   218 a.a. 218   X-ray 2.40 Å
The PDB contains 2 entries of glutathione bound to this target protein
DrugBank nutraceutical Target 21:   UniProt id: P21266 (GSTM3_HUMAN)  -  Glutathione S-transferase Mu 3
UniProt id: P21266    224 a.a.  
3gtu B,D     224 a.a. 224   X-ray 2.80 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 22:   UniProt id: O60760 (HPGDS_HUMAN)  -  Glutathione-requiring prostaglandin D synthase
UniProt id: O60760    198 a.a.  
1. 4edy A,B   198 a.a. 198   X-ray 1.72 Å
  2. 4ec0 A,B   199 a.a. 198   X-ray 1.85 Å
  3. 2vcq A,B,C,D   198 a.a. 198   X-ray 1.95 Å
  4. 2vcw A,B,C   198 a.a. 198   X-ray 1.95 Å
  5. 2vcz A,B,D   198 a.a. 198   X-ray 1.95 Å
   more ...
The PDB contains 20 entries of glutathione bound to this target protein
DrugBank nutraceutical Target 23:   UniProt id: O15217 (GSTA4_HUMAN)  -  Glutathione S-transferase A4
UniProt id: O15217    221 a.a.  
1. 3ik7 A,B,C,D     221 a.a. 221   X-ray 1.97 Å
  2. 1gul A,B,C,D,...     217 a.a. 217   X-ray 2.70 Å
  3. 1gum A,B,C,D,...     217 a.a. 217   X-ray 3.00 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 24:   UniProt id: Q03013 (GSTM4_HUMAN)  -  Glutathione S-transferase Mu 4
UniProt id: Q03013    217 a.a.  
4gtu A,B,C,D,...     217 a.a. 217   X-ray 3.30 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 25:   UniProt id: Q7RTV2 (GSTA5_HUMAN)  -  Glutathione S-transferase A5
UniProt id: Q7RTV2    222 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 26:   UniProt id: P09211 (GSTP1_HUMAN)  -  Glutathione S-transferase P
UniProt id: P09211    209 a.a.  
1. 3gus A,B   209 a.a. 209   X-ray 1.53 Å
  2. 3csh A,B   209 a.a. 209   X-ray 1.55 Å
  3. 1aqw A,B,C,D   209 a.a. 209   X-ray 1.80 Å
  4. 13gs A,B   210 a.a. 209   X-ray 1.90 Å
  5. 8gss A,B,C   209 a.a. 209   X-ray 1.90 Å
   more ...
The PDB contains 23 entries of glutathione bound to this target protein and 54 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 27:   UniProt id: P78417 (GSTO1_HUMAN)  -  Glutathione transferase omega-1
UniProt id: P78417    240 a.a.  
1. 1eem A   237 a.a. 237   X-ray 2.00 Å
  2. 3lfl A,B   236 a.a. 236   X-ray 2.10 Å
The PDB contains 3 entries of glutathione bound to this target protein and 4 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 28:   UniProt id: P07203 (GPX1_HUMAN)  -  Glutathione peroxidase 1
UniProt id: P07203    201 a.a.  
2f8a A,B     186 a.a. 183   X-ray 1.50 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 29:   UniProt id: P18283 (GPX2_HUMAN)  -  Glutathione peroxidase 2
UniProt id: P18283    188 a.a.  
2he3 A     185 a.a. 182   X-ray 2.10 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 30:   UniProt id: P30711 (GSTT1_HUMAN)  -  Glutathione S-transferase theta-1
UniProt id: P30711    239 a.a.  
1. 2c3n A,B,C,D     239 a.a. 239   X-ray 1.50 Å
  2. 2c3q A,B,C,D     239 a.a. 238   X-ray 1.85 Å
  3. 2c3t A,B,C,D     239 a.a. 238   X-ray 2.40 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 31:   UniProt id: O43708 (MAAI_HUMAN)  -  Maleylacetoacetate isomerase
UniProt id: O43708    215 a.a.  
1fw1 A   208 a.a. 206   X-ray 1.90 Å
The PDB contains 1 entry of glutathione bound to this target protein
DrugBank nutraceutical Target 32:   UniProt id: O75715 (GPX5_HUMAN)  -  Epididymal secretory glutathione peroxidase
UniProt id: O75715    220 a.a.  
2i3y A     188 a.a. 188   X-ray 2.00 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 33:   UniProt id: O95881 (TXD12_HUMAN)  -  Thioredoxin domain-containing protein 12
UniProt id: O95881    171 a.a.  
1. 2k8v A     157 a.a. 149   NMR  
  2. 1sen A     135 a.a. 135   X-ray 1.20 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 34:   UniProt id: P22352 (GPX3_HUMAN)  -  Glutathione peroxidase 3
UniProt id: P22352    224 a.a.  
2r37 A,B     191 a.a. 185   X-ray 1.85 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 35:   UniProt id: P08263 (GSTA1_HUMAN)  -  Glutathione S-transferase A1
UniProt id: P08263    221 a.a.  
1. 1gse A,B   221 a.a. 220   X-ray 2.00 Å
  2. 1pkw A,B   220 a.a. 219   X-ray 2.00 Å
  3. 1usb A,B   220 a.a. 219   X-ray 2.07 Å
  4. 3i6a A,B,C,D,...   219 a.a. 206   X-ray 1.98 Å
  5. 3i69 A,B,C,D,...   219 a.a. 206   X-ray 2.38 Å
The PDB contains 6 entries of glutathione bound to this target protein and 27 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 36:   UniProt id: P09210 (GSTA2_HUMAN)  -  Glutathione S-transferase A2
  No Pfam domain assignments available for this protein.
1. 2wju A,B,C,D,...   221 a.a. 220   X-ray 2.30 Å
  2. 4acs A,B,C,D   219 a.a. 215   X-ray 2.10 Å
The PDB contains 2 entries of glutathione bound to this target protein and 5 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 37:   UniProt id: P10620 (MGST1_HUMAN)  -  Microsomal glutathione S-transferase 1
UniProt id: P10620    155 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 38:   UniProt id: P10768 (ESTD_HUMAN)  -  S-formylglutathione hydrolase
UniProt id: P10768    281 a.a.  
3fcx A     268 a.a. 266   X-ray 1.50 Å
There are no PDB entries containing glutathione bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 39:   UniProt id: P19440 (GGT1_HUMAN)  -  Gamma-glutamyltranspeptidase 1
UniProt id: P19440    568 a.a.  
1. 4gg2 A     343 a.a. 343   X-ray 2.21 Å
  2. 4gdx A     342 a.a. 341   X-ray 1.67 Å
There are no PDB entries containing glutathione bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 40:   UniProt id: P28161 (GSTM2_HUMAN)  -  Glutathione S-transferase Mu 2
UniProt id: P28161    217 a.a.  
1. 1xw5 A,B   217 a.a. 217   X-ray 1.80 Å
  2. 3gur A,B,C,D   217 a.a. 217   X-ray 2.50 Å
The PDB contains 2 entries of glutathione bound to this target protein and 10 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with glutathione bound in the PDB

There are 138 "non-target" proteins in the PDB containing the glutathione molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above. Only 10 of the 138 proteins are listed below.

Protein 1:   UniProt id: A3STM0 ()  -  Glutathione S-transferase, putative OS=Sulfitobacter sp. NAS-14.1 GN=NAS141_10626 PE=1 SV=1
UniProt id: A3STM0    206 a.a.  
4gf0 A   208 a.a. 206   X-ray 1.75 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 2:   UniProt id: A4I8P2 ()  -  Thiol-dependent reductase 1 OS=Leishmania infantum GN=TDR1 PE=1 SV=1
UniProt id: A4I8P2    449 a.a.  
4ags A,B,C   445 a.a. 445   X-ray 2.30 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 3:   UniProt id: A5E437 ()  -  Putative uncharacterized protein OS=Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) GN=LELG_04376 PE=1 SV=1
UniProt id: A5E437    221 a.a.  
4ivf A,B,C,D,...   221 a.a. 220   X-ray 2.20 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 4:   UniProt id: A5EI34 ()  -  Putative glutathione S-transferase enzyme with thioredoxin-like domain OS=Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) GN=BBta_3750 PE=1 SV=1
UniProt id: A5EI34    233 a.a.  
4nhz A,D,E,F,...   232 a.a. 232   X-ray 1.90 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 5:   UniProt id: A6L2G9 ()  -  Putative thiol-disulfide oxidoreductase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=BVU_2223 PE=1 SV=1
UniProt id: A6L2G9    391 a.a.  
4grf A   140 a.a. 138   X-ray 1.76 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 6:   UniProt id: A6TBY7 ()  -  Putative glutathione S-transferase OS=Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) GN=yfcF PE=1 SV=1
UniProt id: A6TBY7    211 a.a.  
4jbb A   208 a.a. 208   X-ray 1.48 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 7:   UniProt id: A7ILT8 ()  -  Glutathione S-transferase domain OS=Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) GN=Xaut_3756 PE=1 SV=1
UniProt id: A7ILT8    208 a.a.  
4hz2 A,B   205 a.a. 204   X-ray 1.50 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 8:   UniProt id: A7JQU5 ()  -  Glutathione transferase OS=Mannheimia haemolytica PHL213 GN=MHA_0454 PE=1 SV=1
UniProt id: A7JQU5    209 a.a.  
4iw9 A,B,C   210 a.a. 209   X-ray 1.76 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 9:   UniProt id: A8R5V3 ()  -  Omega-class glutathione S-transferase OS=Bombyx mori GN=gsto PE=2 SV=1
UniProt id: A8R5V3    255 a.a.  
3wd6 A,B,C,D   242 a.a. 242   X-ray 2.50 Å
The PDB contains 1 entry of glutathione bound to this protein
Protein 10:   UniProt id: B1FXZ2 ()  -  Glutathione S-transferase domain OS=Burkholderia graminis C4D1M GN=BgramDRAFT_1843 PE=1 SV=1
UniProt id: B1FXZ2    234 a.a.  
1. 4mf5 A   238 a.a. 234   X-ray 1.11 Å
  2. 4mf6 A   240 a.a. 234   X-ray 1.20 Å
The PDB contains 2 entries of glutathione bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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