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DB00142 : l-glutamic acid

Approved nutraceutical l-glutamic acid ... 70 targets DB00142

Generic name: l-glutamic acid PDB Het Group: GGL
 
2 structures in PDB
Brand name(s): aciglut, glusate, glutacid, glutamicol, glutamidex, glutaminol, glutaton.
Formula: C5H9No4
IUPAC Formula: (2s)-2-Aminopentanedioic acid
PDB name: Gamma-L-Glutamic acid

70
There are 70 target proteins defined in DrugBank for this nutraceutical.
 27 
27 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: O15382 (BCAT2_HUMAN)  -  Branched-chain-amino-acid aminotransferase, mitochondrial
UniProt id: O15382    391 a.a.  
1. 1kta A,B     365 a.a. 364   X-ray 1.90 Å
  2. 1ekf A,B     365 a.a. 364   X-ray 1.95 Å
  3. 1ekv A,B     365 a.a. 364   X-ray 2.25 Å
  4. 1ekp A,B     365 a.a. 364   X-ray 2.50 Å
  5. 2a1h A,B     363 a.a. 362   X-ray 1.80 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 2:   UniProt id: O15399 (NMDE4_HUMAN)  -  Glutamate [NMDA] receptor subunit epsilon-4
UniProt id: O15399    1336 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: O43424 (GRID2_HUMAN)  -  Glutamate receptor delta-2 subunit
UniProt id: O43424    1007 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: O60391 (NMD3B_HUMAN)  -  Glutamate [NMDA] receptor subunit 3B
UniProt id: O60391    1043 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: O75879 (GATB_HUMAN)  -  Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
UniProt id: O75879    557 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 6:   UniProt id: O94925 (GLSK_HUMAN)  -  Glutaminase kidney isoform, mitochondrial
UniProt id: O94925    668 a.a.  
1. 3uo9 A,B,C,D     411 a.a. 410   X-ray 2.30 Å
  2. 3unw A,B,C,D     407 a.a. 407   X-ray 2.56 Å
  3. 3voy A     315 a.a. 313   X-ray 2.20 Å
  4. 3vp1 A     313 a.a. 311   X-ray 2.30 Å
  5. 4o7d A     313 a.a. 311   X-ray 2.30 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 7:   UniProt id: P00505 (AATM_HUMAN)  -  Aspartate aminotransferase, mitochondrial
UniProt id: P00505    430 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 8:   UniProt id: P07814 (SYEP_HUMAN)  -  Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
UniProt id: P07814    1511 a.a.  
1. 4k87 A     490 a.a. 490   X-ray 2.30 Å
  2. 4k88 A     490 a.a. 490   X-ray 2.62 Å
  3. 4k86 A     488 a.a. 488   X-ray 2.40 Å
  4. 4hvc A,B     482 a.a. 482   X-ray 2.00 Å
  5. 1fyj A     57 a.a. 57   NMR  
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 9:   UniProt id: P08243 (ASNS_HUMAN)  -  Asparagine synthetase [glutamine-hydrolyzing]
UniProt id: P08243    561 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 10:   UniProt id: P15104 (GLNA_HUMAN)  -  Glutamine synthetase
UniProt id: P15104    373 a.a.  
1. 2qc8 A,B,C,D,...     356 a.a. 356   X-ray 2.60 Å
  2. 2ojw A,B,C,D,E     360 a.a. 355   X-ray 2.05 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 11:   UniProt id: Q13255 (GRM1_HUMAN)  -  Metabotropic glutamate receptor 1
UniProt id: Q13255    1193 a.a.  
3ks9 A,B     445 a.a. 444   X-ray 1.90 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 12:   UniProt id: P17174 (AATC_HUMAN)  -  Aspartate aminotransferase, cytoplasmic
UniProt id: P17174    412 a.a.  
3ii0 A,B,C,D     405 a.a. 398   X-ray 2.05 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 13:   UniProt id: P17735 (ATTY_HUMAN)  -  Tyrosine aminotransferase
UniProt id: P17735    453 a.a.  
3dyd A,B     388 a.a. 388   X-ray 2.30 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 14:   UniProt id: P24298 (ALAT1_HUMAN)  -  Alanine aminotransferase 1
UniProt id: P24298    496 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 15:   UniProt id: P38435 (VKGC_HUMAN)  -  Vitamin K-dependent gamma-carboxylase
UniProt id: P38435    758 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 16:   UniProt id: P43003 (EAA1_HUMAN)  -  Excitatory amino acid transporter 1
UniProt id: P43003    542 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 17:   UniProt id: P43004 (EAA2_HUMAN)  -  Excitatory amino acid transporter 2
UniProt id: P43004    574 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 18:   UniProt id: P43005 (EAA3_HUMAN)  -  Excitatory amino acid transporter 3
UniProt id: P43005    524 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 19:   UniProt id: P48506 (GSH1_HUMAN)  -  Glutamate--cysteine ligase catalytic subunit
UniProt id: P48506    637 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 20:   UniProt id: P48664 (EAA4_HUMAN)  -  Excitatory amino acid transporter 4
UniProt id: P48664    564 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 21:   UniProt id: P49448 (DHE4_HUMAN)  -  Glutamate dehydrogenase 2, mitochondrial
UniProt id: P49448    558 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 22:   UniProt id: Q14833 (GRM4_HUMAN)  -  Metabotropic glutamate receptor 4
UniProt id: Q14833    912 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 23:   UniProt id: P49915 (GUAA_HUMAN)  -  GMP synthase [glutamine-hydrolyzing]
UniProt id: P49915    692 a.a.  
1. 2vxo A,B     643 a.a. 643   X-ray 2.50 Å
  2. 2vpi A,B     187 a.a. 186   X-ray 2.40 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 24:   UniProt id: P54687 (BCAT1_HUMAN)  -  Branched-chain-amino-acid aminotransferase, cytosolic
UniProt id: P54687    385 a.a.  
1. 2abj A,D,G,J     366 a.a. 362   X-ray 2.20 Å
  2. 2coj A,B     359 a.a. 358   X-ray 2.40 Å
  3. 2coi A,B     358 a.a. 357   X-ray 1.90 Å
  4. 2cog A,B     358 a.a. 357   X-ray 2.10 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 25:   UniProt id: P80404 (GABT_HUMAN)  -  4-aminobutyrate aminotransferase, mitochondrial
UniProt id: P80404    500 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 26:   UniProt id: Q05586 (NMDZ1_HUMAN)  -  Glutamate [NMDA] receptor subunit zeta-1
UniProt id: Q05586    937 a.a.  
1. 2nr1 A     23 a.a. 23   NMR  
  2. 2hqw B     22 a.a. 22   X-ray 1.90 Å
  3. 3bya B     20 a.a. 20   X-ray 1.85 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 27:   UniProt id: Q05932 (FOLC_HUMAN)  -  Folylpolyglutamate synthase, mitochondrial
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 28:   UniProt id: Q07075 (AMPE_HUMAN)  -  Glutamyl aminopeptidase
UniProt id: Q07075    956 a.a.  
1. 4kx7 A     875 a.a. 873   X-ray 2.15 Å
  2. 4kxd A     875 a.a. 873   X-ray 2.15 Å
  3. 4kx9 A     875 a.a. 873   X-ray 2.25 Å
  4. 4kx8 A     875 a.a. 873   X-ray 2.40 Å
  5. 4kxa A     875 a.a. 873   X-ray 2.40 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 29:   UniProt id: Q12879 (NMDE1_HUMAN)  -  Glutamate [NMDA] receptor subunit epsilon-1
UniProt id: Q12879    1464 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 30:   UniProt id: Q13224 (NMDE2_HUMAN)  -  Glutamate [NMDA] receptor subunit epsilon-2
UniProt id: Q13224    1483 a.a.  
1. 1s11 A     141 a.a. 141   Theor. model
  2. 1s2s A     139 a.a. 139   Theor. model
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 31:   UniProt id: Q14957 (NMDE3_HUMAN)  -  Glutamate [NMDA] receptor subunit epsilon-3
UniProt id: Q14957    1233 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 32:   UniProt id: Q2TU84 (Q2TU84_HUMAN)  -  Growth-inhibiting protein 18
UniProt id: Q2TU84    413 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 33:   UniProt id: Q16099 (GRIK4_HUMAN)  -  Glutamate receptor, ionotropic kainate 4
UniProt id: Q16099    956 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 34:   UniProt id: Q5JPH6 (SYEM_HUMAN)  -  Probable glutamyl-tRNA synthetase, mitochondrial
UniProt id: Q5JPH6    523 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 35:   UniProt id: Q5TDP6 (LGSN_HUMAN)  -  Glutamate--ammonia ligase domain-containing protein 1
UniProt id: Q5TDP6    509 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 36:   UniProt id: Q6IA69 (NADE_HUMAN)  -  Glutamine-dependent NAD(+) synthetase
UniProt id: Q6IA69    706 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 37:   UniProt id: Q6YP21 (KAT3_HUMAN)  -  Kynurenine--oxoglutarate transaminase 3
UniProt id: Q6YP21    454 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 38:   UniProt id: Q8N159 (NAGS_HUMAN)  -  N-acetylglutamate synthase, mitochondrial
UniProt id: Q8N159    533 a.a.  
4k30 A,B,X,Y     153 a.a. 151   X-ray 2.10 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 39:   UniProt id: Q8N5Z0 (AADAT_HUMAN)  -  Kynurenine/alpha-aminoadipate aminotransferase mitochondrial
UniProt id: Q8N5Z0    424 a.a.  
1. 2r2n A,B,C,D     425 a.a. 424   X-ray 1.95 Å
  2. 4geb A,B     428 a.a. 422   X-ray 2.15 Å
  3. 2qlr A,B,C,D     424 a.a. 422   X-ray 2.30 Å
  4. 4ge9 A,B,C,D     428 a.a. 422   X-ray 2.43 Å
  5. 4ge7 A,B     427 a.a. 421   X-ray 2.10 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 40:   UniProt id: Q8TCU5 (NMD3A_HUMAN)  -  Glutamate [NMDA] receptor subunit 3A
UniProt id: Q8TCU5    1115 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 41:   UniProt id: Q8TD30 (ALAT2_HUMAN)  -  Alanine aminotransferase 2
UniProt id: Q8TD30    522 a.a.  
3ihj A     461 a.a. 454   X-ray 2.30 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 42:   UniProt id: Q9H1K4 (GHC2_HUMAN)  -  Mitochondrial glutamate carrier 2
UniProt id: Q9H1K4    315 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 43:   UniProt id: Q9H936 (GHC1_HUMAN)  -  Mitochondrial glutamate carrier 1
UniProt id: Q9H936    323 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 44:   UniProt id: Q16478 (GRIK5_HUMAN)  -  Glutamate receptor, ionotropic kainate 5
UniProt id: Q16478    980 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 45:   UniProt id: Q9UDR5 (AASS_HUMAN)  -  Alpha-aminoadipic semialdehyde synthase, mitochondrial
UniProt id: Q9UDR5    926 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 46:   UniProt id: Q9UI32 (GLSL_HUMAN)  -  Glutaminase liver isoform, mitochondrial
UniProt id: Q9UI32    601 a.a.  
4bqm A     296 a.a. 290   X-ray 2.18 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 47:   UniProt id: Q9ULA0 (DNPEP_HUMAN)  -  Aspartyl aminopeptidase
UniProt id: Q9ULA0    474 a.a.  
4dyo A     457 a.a. 454   X-ray 2.20 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 48:   UniProt id: Q9ULK0 (GRID1_HUMAN)  -  Glutamate receptor delta-1 subunit
UniProt id: Q9ULK0    1009 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 49:   UniProt id: Q9UPY5 (XCT_HUMAN)  -  Cystine/glutamate transporter
UniProt id: Q9UPY5    501 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 50:   UniProt id: Q9Y646 (CBPQ_HUMAN)  -  Plasma glutamate carboxypeptidase
UniProt id: Q9Y646    472 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 51:   UniProt id: Q9Y617 (SERC_HUMAN)  -  Phosphoserine aminotransferase
UniProt id: Q9Y617    369 a.a.  
3e77 A,B,C     363 a.a. 354   X-ray 2.50 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 52:   UniProt id: P00367 (DHE3_HUMAN)  -  Glutamate dehydrogenase 1, mitochondrial
UniProt id: P00367    557 a.a.  
1. 1l1f A,B,C,D,...     496 a.a. 496   X-ray 2.70 Å
  2. 1nr1 A,B,C,D,...     496 a.a. 495   X-ray 3.30 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 53:   UniProt id: P39086 (GRIK1_HUMAN)  -  Glutamate receptor, ionotropic kainate 1
UniProt id: P39086    917 a.a.  
1. 4mf3 A,B     258 a.a. 258   X-ray 3.00 Å
  2. 3fv1 A,B     256 a.a. 256   X-ray 1.50 Å
  3. 3fv2 A,B     256 a.a. 256   X-ray 1.50 Å
  4. 3fvg A,B     256 a.a. 256   X-ray 1.50 Å
  5. 3fvk A,B     256 a.a. 256   X-ray 1.50 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 54:   UniProt id: P42261 (GRIA1_HUMAN)  -  Glutamate receptor 1
UniProt id: P42261    906 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 55:   UniProt id: Q14831 (GRM7_HUMAN)  -  Metabotropic glutamate receptor 7
UniProt id: Q14831    914 a.a.  
3mq4 A     386 a.a. 385   X-ray 2.80 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 56:   UniProt id: P48507 (GSH0_HUMAN)  -  Glutamate--cysteine ligase regulatory subunit
UniProt id: P48507    274 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 57:   UniProt id: Q04609 (FOLH1_HUMAN)  -  Glutamate carboxypeptidase 2
UniProt id: Q04609    749 a.a.  
1. 4ngn A     696 a.a. 696   X-ray 1.64 Å
  2. 4ngs A     696 a.a. 696   X-ray 1.68 Å
  3. 4ngm A     696 a.a. 696   X-ray 1.84 Å
  4. 4ngp A     695 a.a. 695   X-ray 1.63 Å
  5. 3sjg A     696 a.a. 695   X-ray 1.65 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 48 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 58:   UniProt id: Q05329 (DCE2_HUMAN)  -  Glutamate decarboxylase 2
UniProt id: Q05329    584 a.a.  
1. 2okk A     482 a.a. 481   X-ray 2.30 Å
  2. 1es0 B     190 a.a. 22   X-ray 2.60 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 59:   UniProt id: Q99259 (DCE1_HUMAN)  -  Glutamate decarboxylase 1
UniProt id: Q99259    593 a.a.  
1. 2okj A,B     500 a.a. 499   X-ray 2.30 Å
  2. 3vp6 A,B     499 a.a. 494   X-ray 2.10 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 60:   UniProt id: O95954 (FTCD_HUMAN)  -  Formimidoyltransferase-cyclodeaminase
UniProt id: O95954    541 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 61:   UniProt id: P42262 (GRIA2_HUMAN)  -  Glutamate receptor 2
UniProt id: P42262    882 a.a.  
1. 2wjw A     368 a.a. 368   X-ray 1.80 Å
  2. 2wjx A,B,C     363 a.a. 363   X-ray 4.10 Å
  3. 3r7x A,B     259 a.a. 258   X-ray 2.10 Å
  4. 3rnn A,B,C     259 a.a. 257   X-ray 1.75 Å
  5. 3rn8 A,B,C     258 a.a. 256   X-ray 1.70 Å
   more ...
There are no PDB entries containing l-glutamic acid bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 62:   UniProt id: P42263 (GRIA3_HUMAN)  -  Glutamate receptor 3
UniProt id: P42263    894 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 63:   UniProt id: P48058 (GRIA4_HUMAN)  -  Glutamate receptor 4
UniProt id: P48058    902 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 64:   UniProt id: P54886 (P5CS_HUMAN)  -  Delta 1-pyrroline-5-carboxylate synthetase
UniProt id: P54886    794 a.a.  
2h5g A,B     417 a.a. 417   X-ray 2.25 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 65:   UniProt id: Q13002 (GRIK2_HUMAN)  -  Glutamate receptor, ionotropic kainate 2
UniProt id: Q13002    907 a.a.  
3qxm A,B     250 a.a. 250   X-ray 1.65 Å
There are no PDB entries containing l-glutamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 66:   UniProt id: O00222 (GRM8_HUMAN)  -  Metabotropic glutamate receptor 8
UniProt id: O00222    908 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 67:   UniProt id: Q13003 (GRIK3_HUMAN)  -  Glutamate receptor, ionotropic kainate 3
UniProt id: Q13003    919 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 68:   UniProt id: O00341 (EAA5_HUMAN)  -  Excitatory amino acid transporter 5
UniProt id: O00341    560 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 69:   UniProt id: O14841 (OPLA_HUMAN)  -  5-oxoprolinase
UniProt id: O14841    1288 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 70:   UniProt id: O15067 (PUR4_HUMAN)  -  Phosphoribosylformylglycinamidine synthase
UniProt id: O15067    1338 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with l-glutamic acid bound in the PDB

There are 2 "non-target" proteins in the PDB containing the l-glutamic acid molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above.

Protein 1:   UniProt id: P18956 ()  -  Gamma-glutamyltranspeptidase OS=Escherichia coli (strain K12) GN=ggt PE=1 SV=1
UniProt id: P18956    579 a.a.  
2dbw A,C   359 a.a. 359   X-ray 1.80 Å
The PDB contains 1 entry of l-glutamic acid bound to this protein
Protein 2:   UniProt id: P42264 ()  -  Glutamate receptor ionotropic, kainate 3 OS=Rattus norvegicus GN=Grik3 PE=1 SV=1
UniProt id: P42264    918 a.a.  
4mh5 A   256 a.a. 255   X-ray 1.65 Å
The PDB contains 1 entry of l-glutamic acid bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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