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DB00131 : adenosine monophosphate

Approved nutraceutical adenosine monophosphate ... 16 targets DB00131

Generic name: adenosine monophosphate PDB Het Group: __A
 
Brand name(s): adenovite, cardiomone, lycedan, my-b-den, phosaden, phosphaden.
Formula: C10H14N5O7P
IUPAC Formula: {[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxyoxolan-2-Yl]methoxy}phosphonic acid
PDB name: Adenosine-5'-Monophosphate

16
There are 16 target proteins defined in DrugBank for this nutraceutical.
 11 
11 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: Q9NR19 (ACSA_HUMAN)  -  Acetyl-coenzyme A synthetase, cytoplasmic
UniProt id: Q9NR19    701 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: Q13131 (AAPK1_HUMAN)  -  5'-AMP-activated protein kinase catalytic subunit alpha-1
UniProt id: Q13131    558 a.a.  
1. 4rer A     458 a.a. 454   X-ray 4.05 Å
  2. 4rew A     411 a.a. 409   X-ray 4.58 Å
  3. 4red A,B     327 a.a. 323   X-ray 2.95 Å
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 3:   UniProt id: O43741 (AAKB2_HUMAN)  -  5'-AMP-activated protein kinase subunit beta-2
UniProt id: O43741    271 a.a.  
1. 4rer B     180 a.a. 179   X-ray 4.05 Å
  2. 2f15 A     89 a.a. 89   X-ray 2.00 Å
  3. 4rew B     79 a.a. 79   X-ray 4.58 Å
  4. 2y94 B     75 a.a. 75   X-ray 3.24 Å
  5. 2v8q B     73 a.a. 73   X-ray 2.10 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 13 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 4:   UniProt id: Q08828 (ADCY1_HUMAN)  -  Adenylate cyclase type 1
UniProt id: Q08828    1119 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: P33121 (ACSL1_HUMAN)  -  Long-chain-fatty-acid--CoA ligase 1
UniProt id: P33121    698 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 6:   UniProt id: P09467 (F16P1_HUMAN)  -  Fructose-1,6-bisphosphatase 1
UniProt id: P09467    337 a.a.  
1. 2jjk A,B,C,D     320 a.a. 319   X-ray 2.00 Å
  2. 2y5k A,B,C,D     320 a.a. 319   X-ray 2.10 Å
  3. 2vt5 A,B,C,D,...     320 a.a. 319   X-ray 2.20 Å
  4. 2y5l A,B,C,D,...     320 a.a. 319   X-ray 2.20 Å
  5. 2wbb A,B,C,D,...     320 a.a. 319   X-ray 2.22 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 7:   UniProt id: P55263 (ADK_HUMAN)  -  Adenosine kinase
UniProt id: P55263    361 a.a.  
1. 1bx4 A     342 a.a. 341   X-ray 1.50 Å
  2. 2i6a A,B,C,D     343 a.a. 341   X-ray 2.20 Å
  3. 2i6b A,B     329 a.a. 326   X-ray 2.30 Å
  4. 4o1l A,B     326 a.a. 326   X-ray 2.50 Å
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 8:   UniProt id: P16220 (CREB1_HUMAN)  -  CAMP response element-binding protein
UniProt id: P16220    340 a.a.  
2lxt C     33 a.a. 32   NMR  
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 9:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 10:   UniProt id: P11309 (PIM1_HUMAN)  -  Proto-oncogene serine/threonine-protein kinase Pim-1
UniProt id: P11309    403 a.a.  
1. 4k18 A     277 a.a. 277   X-ray 2.05 Å
  2. 1xqz A     277 a.a. 277   X-ray 2.10 Å
  3. 1xr1 A     277 a.a. 277   X-ray 2.10 Å
  4. 3f2a A     276 a.a. 275   X-ray 1.90 Å
  5. 3jy0 A     275 a.a. 275   X-ray 2.40 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 99 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 11:   UniProt id: Q07343 (PDE4B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt id: Q07343    735 a.a.  
1. 4wzi A,B     412 a.a. 404   X-ray 2.58 Å
  2. 4x0f A,B     411 a.a. 403   X-ray 3.22 Å
  3. 3g45 A,B     371 a.a. 371   X-ray 2.63 Å
  4. 3hmv A,B     351 a.a. 350   X-ray 2.23 Å
  5. 1f0j A,B     351 a.a. 349   X-ray 1.77 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 39 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 12:   UniProt id: P06737 (PYGL_HUMAN)  -  Glycogen phosphorylase, liver form
UniProt id: P06737    846 a.a.  
1. 1fa9 A     833 a.a. 832   X-ray 2.40 Å
  2. 3dds A,B     810 a.a. 809   X-ray 1.80 Å
  3. 3ddw A,B     810 a.a. 809   X-ray 1.90 Å
  4. 3dd1 A,B     810 a.a. 809   X-ray 2.57 Å
  5. 2qll A     805 a.a. 804   X-ray 2.56 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 18 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 13:   UniProt id: Q9Y478 (AAKB1_HUMAN)  -  5'-AMP-activated protein kinase subunit beta-1
UniProt id: Q9Y478    269 a.a.  
1. 4cff B,D     170 a.a. 169   X-ray 3.92 Å
  2. 4cfe B,D     167 a.a. 166   X-ray 3.02 Å
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 14:   UniProt id: P49773 (HINT1_HUMAN)  -  Histidine triad nucleotide-binding protein 1
UniProt id: P49773    125 a.a.  
1. 3tw2 A,B     116 a.a. 116   X-ray 1.38 Å
  2. 4eqe A,B     114 a.a. 114   X-ray 1.52 Å
  3. 4eqg A,B     114 a.a. 114   X-ray 1.52 Å
  4. 4eqh A,B     114 a.a. 114   X-ray 1.67 Å
  5. 1kpe A,B     113 a.a. 113   X-ray 1.80 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 15:   UniProt id: Q08499 (PDE4D_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4D
UniProt id: Q08499    808 a.a.  
1. 3g58 A,B,C,D     335 a.a. 335   X-ray 2.05 Å
  2. 1oyn A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  3. 2fm0 A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  4. 2fm5 A,B,C,D     334 a.a. 334   X-ray 2.03 Å
  5. 1rko A,B,C,D     334 a.a. 334   X-ray 2.10 Å
   more ...
There are no PDB entries containing adenosine monophosphate bound to this target protein, although there are 39 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 16:   UniProt id: Q9NUB1 (ACS2L_HUMAN)  -  Acetyl-coenzyme A synthetase 2-like, mitochondrial
UniProt id: Q9NUB1    689 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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