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DB00128 : l-aspartic acid

Approved nutraceutical l-aspartic acid ... 24 targets DB00128

Generic name: l-aspartic acid PDB Het Group: IAS
 
1 structure in PDB
Brand name(s): aspatofort.
Formula: C4H7No4
IUPAC Formula: (2s)-2-Aminobutanedioic acid
PDB name: Beta-L-Aspartic acid

24
There are 24 target proteins defined in DrugBank for this nutraceutical.
 13 
13 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the nutraceutical molecule bound to its target protein.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P00505 (AATM_HUMAN)  -  Aspartate aminotransferase, mitochondrial
UniProt id: P00505    430 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 2:   UniProt id: P14868 (SYDC_HUMAN)  -  Aspartyl-tRNA synthetase, cytoplasmic
UniProt id: P14868    500 a.a.  
4j15 A,B     431 a.a. 431   X-ray 2.24 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 3:   UniProt id: O75746 (CMC1_HUMAN)  -  Calcium-binding mitochondrial carrier protein Aralar1
UniProt id: O75746    678 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: Q12797 (ASPH_HUMAN)  -  Aspartyl/asparaginyl beta-hydroxylase
UniProt id: Q12797    758 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: P22234 (PUR6_HUMAN)  -  Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase
UniProt id: P22234    424 a.a.  
2h31 A     386 a.a. 386   X-ray 2.80 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 6:   UniProt id: P27708 (PYR1_HUMAN)  -  CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase
UniProt id: P27708    2224 a.a.  
1. 4c6e A     363 a.a. 362   X-ray 1.26 Å
  2. 4c6f A     363 a.a. 362   X-ray 1.26 Å
  3. 4c6j A     362 a.a. 361   X-ray 1.30 Å
  4. 4c6i A     362 a.a. 361   X-ray 1.35 Å
  5. 4c6k A     362 a.a. 361   X-ray 1.48 Å
   more ...
There are no PDB entries containing l-aspartic acid bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 7:   UniProt id: P30520 (PURA2_HUMAN)  -  Adenylosuccinate synthetase isozyme 2
UniProt id: P30520    455 a.a.  
2v40 A     419 a.a. 419   X-ray 1.90 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 8:   UniProt id: P43005 (EAA3_HUMAN)  -  Excitatory amino acid transporter 3
UniProt id: P43005    524 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: Q2TU84 (Q2TU84_HUMAN)  -  Growth-inhibiting protein 18
UniProt id: Q2TU84    413 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 10:   UniProt id: Q5SY84 (Q5SY84_HUMAN)  -  Adenylosuccinate synthetase
UniProt id: Q5SY84    86 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 11:   UniProt id: P07998 (RNAS1_HUMAN)  -  Ribonuclease pancreatic
UniProt id: P07998    155 a.a.  
1. 2k11 A     127 a.a. 127   NMR  
  2. 2e0j A,B     128 a.a. 126   X-ray 1.60 Å
  3. 1z7x X,Z     126 a.a. 126   X-ray 1.95 Å
  4. 2q4g X,Z     126 a.a. 126   X-ray 1.95 Å
  5. 2e0l A,B     128 a.a. 125   X-ray 1.60 Å
   more ...
There are no PDB entries containing l-aspartic acid bound to this target protein, although there are 12 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 12:   UniProt id: Q5T6L4 (Q5T6L4_HUMAN)  -  Argininosuccinate synthase
UniProt id: Q5T6L4    412 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 13:   UniProt id: Q6PI48 (SYDM_HUMAN)  -  Aspartyl-tRNA synthetase, mitochondrial
UniProt id: Q6PI48    644 a.a.  
4ah6 A,B,C,D     589 a.a. 589   X-ray 3.70 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 14:   UniProt id: Q7L266 (ASGL1_HUMAN)  -  ASRGL1 protein
UniProt id: Q7L266    307 a.a.  
4o0h A,B   295 a.a. 293   X-ray 1.97 Å
The PDB contains 1 entry of l-aspartic acid bound to this target protein and 20 entries of this target protein in all (click on orange, plus icon for list).
DrugBank nutraceutical Target 15:   UniProt id: Q8N142 (PURA1_HUMAN)  -  Adenylosuccinate synthetase isozyme 1
UniProt id: Q8N142    456 a.a.  
2gjo A     431 a.a. 431   Theor. model
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 16:   UniProt id: Q96HD9 (ACY3_HUMAN)  -  Aspartoacylase-2
UniProt id: Q96HD9    319 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 17:   UniProt id: P61626 (LYSC_HUMAN)  -  Lysozyme C
UniProt id: P61626    147 a.a.  
1. 1c46 A     131 a.a. 131   X-ray 2.20 Å
  2. 2nwd X     130 a.a. 130   X-ray 1.04 Å
  3. 1jsf A     130 a.a. 130   X-ray 1.15 Å
  4. 1iwt A     130 a.a. 130   X-ray 1.40 Å
  5. 1iwu A     130 a.a. 130   X-ray 1.40 Å
   more ...
There are no PDB entries containing l-aspartic acid bound to this target protein, although there are 205 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 18:   UniProt id: Q9UJS0 (CMC2_HUMAN)  -  Calcium-binding mitochondrial carrier protein Aralar2
UniProt id: Q9UJS0    675 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 19:   UniProt id: P17174 (AATC_HUMAN)  -  Aspartate aminotransferase, cytoplasmic
UniProt id: P17174    412 a.a.  
3ii0 A,B,C,D     405 a.a. 398   X-ray 2.05 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 20:   UniProt id: Q546F9 (CMC2_HUMAN)  -  Mitochondrial aspartate-glutamate carrier protein
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 21:   UniProt id: P45381 (ACY2_HUMAN)  -  Aspartoacylase
UniProt id: P45381    312 a.a.  
1. 2o53 A,B     302 a.a. 302   X-ray 2.70 Å
  2. 2i3c A,B     302 a.a. 302   X-ray 2.80 Å
  3. 2q51 A,B     302 a.a. 302   X-ray 2.80 Å
  4. 2o4h A,B     301 a.a. 301   X-ray 2.70 Å
  5. 4mri A,B     302 a.a. 301   X-ray 2.80 Å
   more ...
There are no PDB entries containing l-aspartic acid bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 22:   UniProt id: P08243 (ASNS_HUMAN)  -  Asparagine synthetase [glutamine-hydrolyzing]
UniProt id: P08243    561 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 23:   UniProt id: P00966 (ASSY_HUMAN)  -  Argininosuccinate synthase
UniProt id: P00966    411 a.a.  
2nz2 A     402 a.a. 402   X-ray 2.40 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 24:   UniProt id: Q03154 (ACY1_HUMAN)  -  Aminoacylase-1
UniProt id: Q03154    407 a.a.  
1q7l A,C     192 a.a. 192   X-ray 1.40 Å
There are no PDB entries containing l-aspartic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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