spacer
spacer

Search 

DB00125 : l-arginine

Approved nutraceutical l-arginine ... 9 targets DB00125

Generic name: l-arginine
 
Brand name(s): argamine, argivene, detoxargin, levargin, minophagen a, r-gene 10.
Formula: C6H14N4O2
IUPAC Formula: (2s)-2-Amino-5-Carbamimidamidopentanoic acid

9
There are 9 target proteins defined in DrugBank for this nutraceutical.
 5 
5 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P29474 (NOS3_HUMAN)  -  Nitric-oxide synthase, endothelial
UniProt id: P29474    1202 a.a.  
1. 1m9m A,B     400 a.a. 400   X-ray 1.96 Å
  2. 1m9k A,B     400 a.a. 400   X-ray 2.01 Å
  3. 1m9q A,B     400 a.a. 400   X-ray 2.01 Å
  4. 3nos A,B     400 a.a. 400   X-ray 2.40 Å
  5. 1m9j A,B     400 a.a. 400   X-ray 2.43 Å
   more ...
There are no PDB entries containing l-arginine bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 2:   UniProt id: Q8WY07 (CTR3_HUMAN)  -  Cationic amino acid transporter 3
UniProt id: Q8WY07    619 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: Q96A70 (ADC_HUMAN)  -  Arginine decarboxylase
UniProt id: Q96A70    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: P04424 (ARLY_HUMAN)  -  Argininosuccinate lyase
UniProt id: P04424    463 a.a.  
1. 1k62 A,B     450 a.a. 447   X-ray 2.65 Å
  2. 1aos A,B     434 a.a. 432   X-ray 4.20 Å
There are no PDB entries containing l-arginine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 5:   UniProt id: P35228 (NOS2_HUMAN)  -  Nitric oxide synthase, inducible
UniProt id: P35228    1152 a.a.  
1. 3e7g A,B,C,D     421 a.a. 421   X-ray 2.20 Å
  2. 4nos A,B,C,D     421 a.a. 420   X-ray 2.25 Å
  3. 1nsi A,B,C,D     420 a.a. 420   X-ray 2.55 Å
  4. 2nsi A,B,C,D     420 a.a. 420   X-ray 3.00 Å
  5. 3ej8 A,B,C,D     421 a.a. 419   X-ray 2.55 Å
   more ...
There are no PDB entries containing l-arginine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 6:   UniProt id: P30825 (CTR1_HUMAN)  -  High-affinity cationic amino acid transporter 1
UniProt id: P30825    629 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: P78540 (ARGI2_HUMAN)  -  Arginase-2, mitochondrial
UniProt id: P78540    353 a.a.  
1. 4hze A,B,C     306 a.a. 306   X-ray 1.60 Å
  2. 4i06 A,B,C     306 a.a. 306   X-ray 1.80 Å
  3. 4ixu A,B,C     306 a.a. 306   X-ray 1.90 Å
  4. 4ie2 A,B,C     306 a.a. 306   X-ray 2.21 Å
  5. 4ixv A,B,C     306 a.a. 306   X-ray 2.30 Å
   more ...
There are no PDB entries containing l-arginine bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 8:   UniProt id: O43246 (CTR4_HUMAN)  -  Cationic amino acid transporter 4
UniProt id: O43246    635 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: P00966 (ASSY_HUMAN)  -  Argininosuccinate synthase
UniProt id: P00966    411 a.a.  
2nz2 A     402 a.a. 402   X-ray 2.40 Å
There are no PDB entries containing l-arginine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer