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DB00125 : l-arginine

Approved nutraceutical l-arginine ... 9 targets DB00125

Generic name: l-arginine
 
Brand name(s): argamine, argivene, detoxargin, levargin, minophagen a, r-gene 10.
Formula: C6H14N4O2
IUPAC Formula: (2s)-2-Amino-5-Carbamimidamidopentanoic acid

9
There are 9 target proteins defined in DrugBank for this nutraceutical.
 5 
5 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P29474 (NOS3_HUMAN)  -  Nitric-oxide synthase, endothelial
UniProt id: P29474    1202 a.a.  
1. 4d1p A,B     401 a.a. 401   X-ray 1.73 Å
  2. 4d1o A,B     401 a.a. 401   X-ray 1.82 Å
  3. 1m9m A,B     400 a.a. 400   X-ray 1.96 Å
  4. 1m9k A,B     400 a.a. 400   X-ray 2.01 Å
  5. 1m9q A,B     400 a.a. 400   X-ray 2.01 Å
   more ...
There are no PDB entries containing l-arginine bound to this target protein, although there are 12 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 2:   UniProt id: Q8WY07 (CTR3_HUMAN)  -  Cationic amino acid transporter 3
UniProt id: Q8WY07    619 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: Q96A70 (AZIN2_HUMAN)  -  Arginine decarboxylase
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: P04424 (ARLY_HUMAN)  -  Argininosuccinate lyase
UniProt id: P04424    463 a.a.  
1. 1k62 A,B     450 a.a. 447   X-ray 2.65 Å
  2. 1aos A,B     434 a.a. 432   X-ray 4.20 Å
There are no PDB entries containing l-arginine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 5:   UniProt id: P35228 (NOS2_HUMAN)  -  Nitric oxide synthase, inducible
UniProt id: P35228    1152 a.a.  
1. 3e7g A,B,C,D     421 a.a. 421   X-ray 2.20 Å
  2. 4nos A,B,C,D     421 a.a. 420   X-ray 2.25 Å
  3. 1nsi A,B,C,D     420 a.a. 420   X-ray 2.55 Å
  4. 2nsi A,B,C,D     420 a.a. 420   X-ray 3.00 Å
  5. 3ej8 A,B,C,D     421 a.a. 419   X-ray 2.55 Å
   more ...
There are no PDB entries containing l-arginine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 6:   UniProt id: P30825 (CTR1_HUMAN)  -  High-affinity cationic amino acid transporter 1
UniProt id: P30825    629 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: P78540 (ARGI2_HUMAN)  -  Arginase-2, mitochondrial
UniProt id: P78540    353 a.a.  
1. 4hze A,B,C     306 a.a. 306   X-ray 1.60 Å
  2. 4i06 A,B,C     306 a.a. 306   X-ray 1.80 Å
  3. 4ixu A,B,C     306 a.a. 306   X-ray 1.90 Å
  4. 4ie2 A,B,C     306 a.a. 306   X-ray 2.21 Å
  5. 4ixv A,B,C     306 a.a. 306   X-ray 2.30 Å
   more ...
There are no PDB entries containing l-arginine bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 8:   UniProt id: O43246 (CTR4_HUMAN)  -  Cationic amino acid transporter 4
UniProt id: O43246    635 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: P00966 (ASSY_HUMAN)  -  Argininosuccinate synthase
UniProt id: P00966    411 a.a.  
2nz2 A     402 a.a. 402   X-ray 2.40 Å
There are no PDB entries containing l-arginine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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