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DB00120 : l-phenylalanine

Approved nutraceutical l-phenylalanine ... 7 targets DB00120

Generic name: l-phenylalanine PDB Het Group: DPN
 
18 structures in PDB
Brand name(s): none.
Formula: C9H11No2
IUPAC Formula: (2s)-2-Amino-3-Phenylpropanoic acid
PDB name: D-Phenylalanine

7
There are 7 target proteins defined in DrugBank for this nutraceutical.
 6 
6 of these target proteins have one or more structures in the PDB.
 8 
There are 8 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P17735 (ATTY_HUMAN)  -  Tyrosine aminotransferase
UniProt id: P17735    453 a.a.  
3dyd A,B     388 a.a. 388   X-ray 2.30 Å
There are no PDB entries containing l-phenylalanine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 2:   UniProt id: Q9UHI5 (LAT2_HUMAN)  -  Large neutral amino acids transporter small subunit 2
UniProt id: Q9UHI5    535 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: Q9Y285 (SYFA_HUMAN)  -  Phenylalanyl-tRNA synthetase alpha chain
UniProt id: Q9Y285    507 a.a.  
3l4g A,E,G,I,...     318 a.a. 318   X-ray 3.30 Å
There are no PDB entries containing l-phenylalanine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 4:   UniProt id: P00439 (PH4H_HUMAN)  -  Phenylalanine-4-hydroxylase
UniProt id: P00439    451 a.a.  
1. 2pah A,B     329 a.a. 329   X-ray 3.10 Å
  2. 1mmk A     309 a.a. 309   X-ray 2.00 Å
  3. 4anp A     309 a.a. 309   X-ray 2.11 Å
  4. 1mmt A     308 a.a. 308   X-ray 2.00 Å
  5. 1pah A     308 a.a. 308   X-ray 2.00 Å
   more ...
There are no PDB entries containing l-phenylalanine bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 5:   UniProt id: O95363 (SYFM_HUMAN)  -  Phenylalanyl-tRNA synthetase, mitochondrial
UniProt id: O95363    450 a.a.  
1. 3cmq A     405 a.a. 405   X-ray 2.20 Å
  2. 3teg A     405 a.a. 405   X-ray 2.20 Å
  3. 3hfv A     405 a.a. 405   X-ray 2.60 Å
  4. 3tup A     404 a.a. 404   X-ray 3.05 Å
There are no PDB entries containing l-phenylalanine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 6:   UniProt id: Q9NSD9 (SYFB_HUMAN)  -  Phenylalanyl-tRNA synthetase beta chain
UniProt id: Q9NSD9    588 a.a.  
3l4g B,D,F,H,...     589 a.a. 587   X-ray 3.30 Å
There are no PDB entries containing l-phenylalanine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 7:   UniProt id: P07101 (TY3H_HUMAN)  -  Tyrosine 3-monooxygenase
UniProt id: P07101    527 a.a.  
2xsn A,B,C,D     335 a.a. 334   X-ray 2.68 Å
There are no PDB entries containing l-phenylalanine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with l-phenylalanine bound in the PDB

There are 5 "non-target" proteins in the PDB containing the l-phenylalanine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above.

Protein 1:   UniProt id: P80561 ()  -  Aminopeptidase S OS=Streptomyces griseus PE=1 SV=1
UniProt id: P80561    283 a.a.  
1tkh A   274 a.a. 273   X-ray 1.25 Å
The PDB contains 1 entry of l-phenylalanine bound to this protein
Protein 2:   UniProt id: Q16773 ()  -  Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens GN=CCBL1 PE=1 SV=1
UniProt id: Q16773    421 a.a.  
1w7m A   414 a.a. 412   X-ray 2.70 Å
The PDB contains 1 entry of l-phenylalanine bound to this protein
Protein 3:   UniProt id: Q6PIK1 ()  -  IGL@ protein OS=Homo sapiens GN=IGL@ PE=1 SV=1
UniProt id: Q6PIK1    234 a.a.  
1mcf A,B   216 a.a. 208   X-ray 2.70 Å
The PDB contains 1 entry of l-phenylalanine bound to this protein
Protein 4:   UniProt id: Q9LCC8 ()  -  D-Amino acid amidase OS=Ochrobactrum anthropi GN=daaA PE=1 SV=1
UniProt id: Q9LCC8    362 a.a.  
2dns A,B,C,D,E   362 a.a. 362   X-ray 2.40 Å
The PDB contains 1 entry of l-phenylalanine bound to this protein
Protein 5:   Principles and pitfalls in designing site directed peptide l
  No Pfam domain assignments available for this protein.
1. 1mcd A,B   216 a.a. 216   X-ray 2.70 Å
  2. 1mce A,B   216 a.a. 216   X-ray 2.70 Å
  3. 1mcj A,B   216 a.a. 216   X-ray 2.70 Å
  4. 2dd0 A,B,C,D,E   362 a.a. 21   X-ray 2.40 Å
  5.    " F   333 a.a. 20   "

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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