spacer
spacer

Search 

DB00117 : l-histidine

Approved nutraceutical l-histidine ... 4 targets DB00117

Generic name: l-histidine PDB Het Group: DHI
 
3 structures in PDB
Brand name(s): none.
Formula: C6H9N3O2
IUPAC Formula: (2s)-2-Amino-3-(1h-Imidazol-5-Yl)propanoic acid
PDB name: D-Histidine

4
There are 4 target proteins defined in DrugBank for this nutraceutical.
 2 
2 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the nutraceutical molecule bound to a protein that is not specified as a target.
Links  
DrugBank
ChEBI
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P19113 (DCHS_HUMAN)  -  Histidine decarboxylase
UniProt id: P19113    661 a.a.  
4e1o A,B,C,D,...     476 a.a. 472   X-ray 1.80 Å
There are no PDB entries containing l-histidine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 2:   UniProt id: P12081 (SYHC_HUMAN)  -  Histidyl-tRNA synthetase, cytoplasmic
UniProt id: P12081    509 a.a.  
1. 4phc A,B,C,D     444 a.a. 444   X-ray 2.84 Å
  2. 4g84 A,B     433 a.a. 433   X-ray 2.40 Å
  3. 4g85 A,B     427 a.a. 427   X-ray 3.11 Å
  4. 2lw7 A     170 a.a. 111   NMR  
  5. 1x59 A     73 a.a. 60   NMR  
There are no PDB entries containing l-histidine bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 3:   UniProt id: Q99624 (S38A3_HUMAN)  -  System N amino acid transporter 1
UniProt id: Q99624    504 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: P42357 (HUTH_HUMAN)  -  Histidine ammonia-lyase
UniProt id: P42357    657 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with l-histidine bound in the PDB

There are 2 "non-target" proteins in the PDB containing the l-histidine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the nutraceutical targets listed above.

Protein 1:   UniProt id: Q45070 ()  -  Glucuronoxylanase XynC OS=Bacillus subtilis (strain 168) GN=xynC PE=1 SV=1
UniProt id: Q45070    421 a.a.  
3kl3 A,B,C   389 a.a. 389   X-ray 2.33 Å
The PDB contains 1 entry of l-histidine bound to this protein
Protein 2:   UniProt id: Q8IIS0 ()  -  D-tyrosyl-tRNA(Tyr) deacylase OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0095 PE=1 SV=1
UniProt id: Q8IIS0    163 a.a.  
3koc C   159 a.a. 158   X-ray 2.91 Å
The PDB contains 1 entry of l-histidine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of nutraceutical-protein interactions in all selected structures above.

  spacer

spacer