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DB00116 : tetrahydrofolic acid

Approved nutraceutical tetrahydrofolic acid ... 18 targets DB00116

Generic name: tetrahydrofolic acid
 
Brand name(s): none.
Formula: C19H23N7O6
IUPAC Formula: (2s)-2-[(4-{[(2-Amino-4-Oxo-1,4,5,6,7,8-Hexahydropteridin-6-
Yl)methyl]amino}phenyl)formamido]pentanedioic acid

18
There are 18 target proteins defined in DrugBank for this nutraceutical.
 8 
8 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank nutraceutical Target 1:   UniProt id: P34897 (GLYM_HUMAN)  -  Serine hydroxymethyltransferase, mitochondrial
UniProt id: P34897    503 a.a.  
1. 3ou5 A     422 a.a. 422   X-ray 2.04 Å
  2. 2a7v A     420 a.a. 420   X-ray 2.04 Å
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 2:   UniProt id: P42898 (MTHR_HUMAN)  -  Methylenetetrahydrofolate reductase
UniProt id: P42898    656 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 3:   UniProt id: Q53ET4 (Q53ET4_HUMAN)  -  Serine hydroxymethyltransferase 2
UniProt id: Q53ET4    504 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 4:   UniProt id: Q5BJF5 (Q5BJF5_HUMAN)  -  SHMT2 protein
UniProt id: Q5BJF5    480 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 5:   UniProt id: Q5HYG8 (Q5HYG8_HUMAN)  -  Hypothetical protein DKFZp686P09201
UniProt id: Q5HYG8    483 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 6:   UniProt id: Q5SNW5 (Q5SNW5_HUMAN)  -  5,10-methylenetetrahydrofolate reductase
UniProt id: Q5SNW5    143 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 7:   UniProt id: Q8N1A5 (GLYM_HUMAN)  -  SHMT2 protein
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 8:   UniProt id: Q96DP5 (FMT_HUMAN)  -  Methionyl-tRNA formyltransferase, mitochondrial
UniProt id: Q96DP5    389 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 9:   UniProt id: Q9NY62 (Q9NY62_HUMAN)  -  Methylenetetrahydrofolate reductase intermediate form
UniProt id: Q9NY62    101 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 10:   UniProt id: P11586 (C1TC_HUMAN)  -  C-1-tetrahydrofolate synthase, cytoplasmic
UniProt id: P11586    934 a.a.  
1. 1a4i A,B     285 a.a. 285   X-ray 1.50 Å
  2. 1dia A,B     285 a.a. 285   X-ray 2.20 Å
  3. 1dig A,B     285 a.a. 285   X-ray 2.20 Å
  4. 1dib A,B     285 a.a. 285   X-ray 2.70 Å
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 11:   UniProt id: P13995 (MTDC_HUMAN)  -  Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
UniProt id: P13995    349 a.a.  
1zn4 A,B     278 a.a. 278   Theor. model
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank nutraceutical Target 12:   UniProt id: P48728 (GCST_HUMAN)  -  Aminomethyltransferase, mitochondrial
UniProt id: P48728    402 a.a.  
1. 1wsr A,B     371 a.a. 371   X-ray 2.00 Å
  2. 1wsv A,B     371 a.a. 371   X-ray 2.60 Å
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 13:   UniProt id: Q96IG6 (GCST_HUMAN)  -  AMT protein
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 14:   UniProt id: O75891 (AL1L1_HUMAN)  -  10-formyltetrahydrofolate dehydrogenase
UniProt id: O75891    902 a.a.  
1. 2bw0 A     309 a.a. 307   X-ray 1.70 Å
  2. 2cfi A     310 a.a. 307   X-ray 1.85 Å
  3. 2cq8 A     110 a.a. 99   NMR  
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 15:   UniProt id: Q99707 (METH_HUMAN)  -  Methionine synthase
UniProt id: Q99707    1264 a.a.  
1. 4ccz A     611 a.a. 611   X-ray 2.70 Å
  2. 2o2k A,B     332 a.a. 330   X-ray 1.60 Å
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 16:   UniProt id: O95954 (FTCD_HUMAN)  -  Formimidoyltransferase-cyclodeaminase
UniProt id: O95954    541 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank nutraceutical Target 17:   UniProt id: P31939 (PUR9_HUMAN)  -  Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
UniProt id: P31939    591 a.a.  
1. 1p4r A,B     589 a.a. 589   X-ray 2.55 Å
  2. 1pl0 A,B,C,D     589 a.a. 589   X-ray 2.60 Å
  3. 1pkx A,B,C,D     588 a.a. 588   X-ray 1.90 Å
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank nutraceutical Target 18:   UniProt id: P34896 (GLYC_HUMAN)  -  Serine hydroxymethyltransferase, cytosolic
UniProt id: P34896    482 a.a.  
1bj4 A     470 a.a. 467   X-ray 2.65 Å
There are no PDB entries containing tetrahydrofolic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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