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DB00102 : becaplermin

Approved biotech drug becaplermin ... 3 targets DB00102

Brand name(s): regranex, regranex (omj pharmaceuticals).
UniProt accession: P01127 (PDGFB_HUMAN)

3
There are 3 target proteins defined in DrugBank for this biotech drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank biotech drug Target 1:   UniProt id: P09619 (PGFRB_HUMAN)  -  Beta platelet-derived growth factor receptor
UniProt id: P09619    1105 a.a.  
1. 1lwp A     363 a.a. 363   Theor. model
  2. 3mjg X,Y     274 a.a. 274   X-ray 2.30 Å
  3. 2l6w A,B     39 a.a. 38   NMR  
  4. 1gq5 A     91 a.a. 16   X-ray 2.20 Å
  5. 2pld B     11 a.a. 10   NMR  
There are no PDB entries containing becaplermin bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: P16234 (PGFRA_HUMAN)  -  Alpha platelet-derived growth factor receptor
UniProt id: P16234    1089 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank biotech drug Target 3:   UniProt id: P01023 (A2MG_HUMAN)  -  Alpha-2-macroglobulin
UniProt id: P01023    1473 a.a.  
1. 4acq A,B,D     1269 a.a. 1268   X-ray 4.30 Å
  2. 1bv8 A     138 a.a. 138   NMR  
  3. 2p9r A     102 a.a. 102   X-ray 2.30 Å
There are no PDB entries containing becaplermin bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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