spacer
spacer

Search 

DB00092 : alefacept

Approved biotech drug alefacept ... 11 targets DB00092

Generic name: alefacept
No image
 
Brand name(s): amevive.
Formula: C2306H3594N610O694S26
IUPAC Formula: None

11
There are 11 target proteins defined in DrugBank for this biotech drug.
 11 
11 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank biotech drug Target 1:   UniProt id: P31995 (FCG2C_HUMAN)  -  Low affinity immunoglobulin gamma Fc region receptor II-c
UniProt id: P31995    322 a.a.  
3wjl C     160 a.a. 160   X-ray 2.86 Å
There are no PDB entries containing alefacept bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank biotech drug Target 2:   UniProt id: O75015 (FCG3B_HUMAN)  -  Low affinity immunoglobulin gamma Fc region receptor III-B
UniProt id: O75015    232 a.a.  
1. 1fnl A     173 a.a. 172   X-ray 1.80 Å
  2. 1e4k C     172 a.a. 172   X-ray 3.20 Å
  3. 1e4j A     171 a.a. 171   X-ray 2.50 Å
  4. 1iis C     167 a.a. 167   X-ray 3.00 Å
  5. 1t83 C     167 a.a. 167   X-ray 3.00 Å
   more ...
There are no PDB entries containing alefacept bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 3:   UniProt id: P06729 (CD2_HUMAN)  -  T-cell surface antigen CD2
UniProt id: P06729    350 a.a.  
1. 1hnf A     179 a.a. 179   X-ray 2.50 Å
  2. 1cdb A     105 a.a. 105   NMR  
  3. 1gya A     105 a.a. 105   NMR  
  4. 1qa9 A,C     102 a.a. 99   X-ray 3.20 Å
  5. 1l2z B     11 a.a. 11   NMR  
There are no PDB entries containing alefacept bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 4:   UniProt id: P00736 (C1R_HUMAN)  -  Complement C1r subcomponent
UniProt id: P00736    704 a.a.  
1. 1gpz A,B     369 a.a. 368   X-ray 2.90 Å
  2. 1md8 A     314 a.a. 314   X-ray 2.80 Å
  3. 1md7 A     304 a.a. 303   X-ray 3.20 Å
  4. 2qy0 A,C     154 a.a. 152   X-ray 2.60 Å
  5. 1apq A     53 a.a. 52   NMR  
There are no PDB entries containing alefacept bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 5:   UniProt id: P02745 (C1QA_HUMAN)  -  Complement C1q subcomponent subunit A
UniProt id: P02745    244 a.a.  
1. 2jg9 A,D     134 a.a. 134   X-ray 1.90 Å
  2. 1pk6 A     133 a.a. 133   X-ray 1.85 Å
  3. 2jg8 A,D     133 a.a. 133   X-ray 2.05 Å
  4. 2wnu A,D     133 a.a. 133   X-ray 2.30 Å
  5. 2wnv A,D     132 a.a. 132   X-ray 1.25 Å
There are no PDB entries containing alefacept bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 6:   UniProt id: P02746 (C1QB_HUMAN)  -  Complement C1q subcomponent subunit B
UniProt id: P02746    252 a.a.  
1. 2jg8 B,E     134 a.a. 134   X-ray 2.05 Å
  2. 2jg9 B,E     133 a.a. 133   X-ray 1.90 Å
  3. 2wnu B,E     133 a.a. 133   X-ray 2.30 Å
  4. 2wnv B,E     132 a.a. 132   X-ray 1.25 Å
  5. 1pk6 B     132 a.a. 132   X-ray 1.85 Å
There are no PDB entries containing alefacept bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 7:   UniProt id: P02747 (C1QC_HUMAN)  -  Complement C1q subcomponent subunit C
UniProt id: P02747    244 a.a.  
1. 2jg8 C,F     131 a.a. 131   X-ray 2.05 Å
  2. 2wnv C,F     129 a.a. 129   X-ray 1.25 Å
  3. 1pk6 C     129 a.a. 129   X-ray 1.85 Å
  4. 2jg9 C,F     129 a.a. 129   X-ray 1.90 Å
  5. 2wnu C,F     129 a.a. 129   X-ray 2.30 Å
There are no PDB entries containing alefacept bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 8:   UniProt id: P08637 (FCG3A_HUMAN)  -  Low affinity immunoglobulin gamma Fc region receptor III-A
UniProt id: P08637    253 a.a.  
1. 3sgj C     169 a.a. 165   X-ray 2.20 Å
  2. 3wn5 C,F     169 a.a. 165   X-ray 2.78 Å
  3. 3sgk C     165 a.a. 161   X-ray 2.40 Å
  4. 3ay4 C     160 a.a. 157   X-ray 2.20 Å
There are no PDB entries containing alefacept bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 9:   UniProt id: P12314 (FCGR1_HUMAN)  -  High affinity immunoglobulin gamma Fc receptor I
UniProt id: P12314    373 a.a.  
3rjd A     257 a.a. 257   X-ray 2.65 Å
There are no PDB entries containing alefacept bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank biotech drug Target 10:   UniProt id: P12318 (FCG2A_HUMAN)  -  Low affinity immunoglobulin gamma Fc region receptor II-a
UniProt id: P12318    316 a.a.  
1. 1h9v A     172 a.a. 171   X-ray 3.00 Å
  2. 1fcg A     171 a.a. 170   X-ray 2.00 Å
  3. 3d5o F     171 a.a. 170   X-ray 2.80 Å
  4. 3ry4 A     170 a.a. 169   X-ray 1.50 Å
  5. 3ry5 A     170 a.a. 169   X-ray 2.30 Å
There are no PDB entries containing alefacept bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 11:   UniProt id: P31994 (FCG2B_HUMAN)  -  Low affinity immunoglobulin gamma Fc region receptor II-b
UniProt id: P31994    309 a.a.  
1. 2fcb A     173 a.a. 172   X-ray 1.74 Å
  2. 3wjj C     164 a.a. 164   X-ray 2.60 Å
There are no PDB entries containing alefacept bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of biotech drug-protein interactions in all selected structures above.

  spacer

spacer