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DB00086 : streptokinase

Approved biotech drug streptokinase ... 2 targets DB00086

Brand name(s): streptase (aventis behringer gmbh).
UniProt accession: P00779 (STRP_STREQ)

2
There are 2 target proteins defined in DrugBank for this biotech drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank biotech drug Target 1:   UniProt id: P00747 (PLMN_HUMAN)  -  Plasminogen
UniProt id: P00747    809 a.a.  
1. 4a5t S     767 a.a. 767   X-ray 3.49 Å
  2. 4dur A,B     756 a.a. 756   X-ray 2.45 Å
  3. 4duu A     682 a.a. 682   X-ray 5.20 Å
  4. 1ki0 A     253 a.a. 252   X-ray 1.75 Å
  5. 1bml A,B     250 a.a. 249   X-ray 2.90 Å
   more ...
There are no PDB entries containing streptokinase bound to this target protein, although there are 30 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: P25116 (PAR1_HUMAN)  -  Proteinase-activated receptor 1
UniProt id: P25116    424 a.a.  
1. 3lu9 C,F     25 a.a. 25   X-ray 1.80 Å
  2. 1nrn R     19 a.a. 19   X-ray 3.10 Å
  3. 3hki C     15 a.a. 15   X-ray 2.20 Å
  4. 1nrq R     8 a.a. 2   X-ray 3.50 Å
There are no PDB entries containing streptokinase bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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