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DB00041 : aldesleukin

Approved biotech drug aldesleukin ... 3 targets DB00041

Brand name(s): proleukin, proleukin (chiron corp).
UniProt accession: P60569 (IL2_HYLLA)

3
There are 3 target proteins defined in DrugBank for this biotech drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank biotech drug Target 1:   UniProt id: P14784 (IL2RB_HUMAN)  -  Interleukin-2 receptor subunit beta
  No Pfam domain assignments available for this protein.
1. 1ilm A     61 a.a. 61   Theor. model
  2. 1iln A     61 a.a. 61   Theor. model
  3. 2b5i B     196 a.a. 24   X-ray 2.30 Å
  4. 4gs7 B     192 a.a. 24   X-ray 2.35 Å
  5. 3qaz B,E,H,K,...     195 a.a. 24   X-ray 3.80 Å
There are no PDB entries containing aldesleukin bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: P01589 (IL2RA_HUMAN)  -  Interleukin-2 receptor alpha chain
UniProt id: P01589    271 a.a.  
1. 2erj A,E     130 a.a. 129   X-ray 3.00 Å
  2. 2b5i D     122 a.a. 122   X-ray 2.30 Å
  3. 1z92 B     123 a.a. 121   X-ray 2.80 Å
  4. 3iu3 B,D,L     208 a.a. 31   X-ray 2.90 Å
  5. 1ilm 2     128 a.a. 15   Theor. model
   more ...
There are no PDB entries containing aldesleukin bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 3:   UniProt id: P31785 (IL2RG_HUMAN)  -  Cytokine receptor common gamma chain
UniProt id: P31785    368 a.a.  
1. 2erj C,G     195 a.a. 194   X-ray 3.00 Å
  2. 3bpl C     194 a.a. 193   X-ray 2.93 Å
  3. 1ite B     193 a.a. 193   Theor. model
  4. 1ill G     192 a.a. 192   Theor. model
  5. 2b5i C     191 a.a. 190   X-ray 2.30 Å
   more ...
There are no PDB entries containing aldesleukin bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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