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DB00025 : antihemophilic factor

Approved biotech drug antihemophilic factor ... 11 targets DB00025

Brand name(s): advate, alphanate, bioclate, helixate, helixate fs, hemofil m, humate-p, hyate:c, koate-hp, kogenate, kogenate fs, monarc-m, monoclate-p, refacto, xyntha.
UniProt accession: P00451 (FA8_HUMAN)

11
There are 11 target proteins defined in DrugBank for this biotech drug.
 9 
9 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank biotech drug Target 1:   UniProt id: Q07954 (LRP1_HUMAN)  -  Low-density lipoprotein receptor-related protein 1
UniProt id: Q07954    4543 a.a.  
1. 2fyj A     82 a.a. 82   NMR  
  2. 2fyl B     82 a.a. 82   NMR  
  3. 2knx A     50 a.a. 48   NMR  
  4. 1j8e A     44 a.a. 43   X-ray 1.85 Å
  5. 1d2l A     45 a.a. 43   NMR  
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: Q8NI22 (MCFD2_HUMAN)  -  Multiple coagulation factor deficiency protein 2
UniProt id: Q8NI22    145 a.a.  
1. 2vrg A     80 a.a. 80   NMR  
  2. 3lcp C     68 a.a. 68   X-ray 2.45 Å
  3. 3a4u B     65 a.a. 65   X-ray 1.84 Å
  4. 3wht B     61 a.a. 61   X-ray 1.80 Å
  5. 3whu B     58 a.a. 58   X-ray 2.60 Å
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 3:   UniProt id: P00742 (FA10_HUMAN)  -  Coagulation factor X
UniProt id: P00742    487 a.a.  
1. 1c5m D     241 a.a. 241   X-ray 1.95 Å
  2. 1hcg A     236 a.a. 236   X-ray 2.20 Å
  3. 2xc5 A     235 a.a. 235   X-ray 1.70 Å
  4. 2xbw A     235 a.a. 235   X-ray 1.72 Å
  5. 2uwp A     235 a.a. 235   X-ray 1.75 Å
   more ...
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 128 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 4:   UniProt id: P00740 (FA9_HUMAN)  -  Coagulation factor IX
UniProt id: P00740    460 a.a.  
1. 3lc3 A,C     235 a.a. 235   X-ray 1.90 Å
  2. 3lc5 A     235 a.a. 235   X-ray 2.62 Å
  3. 1rfn A     235 a.a. 235   X-ray 2.80 Å
  4. 2wph E     59 a.a. 59   X-ray 1.50 Å
  5. 2wpj E     59 a.a. 59   X-ray 1.60 Å
   more ...
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 5:   UniProt id: P04275 (VWF_HUMAN)  -  Von Willebrand factor
UniProt id: P04275    2812 a.a.  
1. 1auq A     208 a.a. 207   X-ray 2.30 Å
  2. 1u0n A     208 a.a. 207   X-ray 2.95 Å
  3. 1uex C     202 a.a. 201   X-ray 2.85 Å
  4. 1ijb A     202 a.a. 200   X-ray 1.80 Å
  5. 3hxq A     201 a.a. 200   X-ray 2.69 Å
   more ...
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 28 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 6:   UniProt id: O14832 (PAHX_HUMAN)  -  Phytanoyl-CoA dioxygenase, peroxisomal
UniProt id: O14832    337 a.a.  
2a1x A     253 a.a. 253   X-ray 2.50 Å
There are no PDB entries containing antihemophilic factor bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank biotech drug Target 7:   UniProt id: P07307 (ASGR2_HUMAN)  -  Asialoglycoprotein receptor 2
UniProt id: P07307    311 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank biotech drug Target 8:   UniProt id: P11021 (GRP78_HUMAN)  -  78 kDa glucose-regulated protein
UniProt id: P11021    653 a.a.  
1. 3ldo A,B     382 a.a. 382   X-ray 1.95 Å
  2. 3ldn A,B     382 a.a. 382   X-ray 2.20 Å
  3. 3ldp A,B     381 a.a. 381   X-ray 2.20 Å
  4. 3ldl A,B     381 a.a. 381   X-ray 2.30 Å
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 9:   UniProt id: P27797 (CALR_HUMAN)  -  Calreticulin
UniProt id: P27797    416 a.a.  
1. 3pow A     251 a.a. 249   X-ray 1.55 Å
  2. 3pos A,B,C     249 a.a. 247   X-ray 1.65 Å
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 10:   UniProt id: P27824 (CALX_HUMAN)  -  Calnexin
UniProt id: P27824    592 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank biotech drug Target 11:   UniProt id: P49257 (LMAN1_HUMAN)  -  ERGIC-53 protein
UniProt id: P49257    509 a.a.  
1. 3lcp A,B     234 a.a. 234   X-ray 2.45 Å
  2. 4gkx A,B,C,D,...     230 a.a. 230   X-ray 2.70 Å
  3. 4gky A     229 a.a. 229   X-ray 2.42 Å
  4. 3a4u A     228 a.a. 228   X-ray 1.84 Å
  5. 3whu A     226 a.a. 226   X-ray 2.60 Å
   more ...
There are no PDB entries containing antihemophilic factor bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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