spacer
spacer

Search 

DB00020 : sargramostim

Approved biotech drug sargramostim ... 5 targets DB00020

Brand name(s): immunex, leucomax (novartis), leukine, leukine (berlex laboratories inc).
UniProt accession: P04141 (CSF2_HUMAN)

5
There are 5 target proteins defined in DrugBank for this biotech drug.
 4 
4 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank biotech drug Target 1:   UniProt id: P15509 (CSF2R_HUMAN)  -  Granulocyte-macrophage colony-stimulating factor receptor alpha chain
UniProt id: P15509    399 a.a.  
3cxe C     99 a.a. 82   X-ray 3.30 Å
There are no PDB entries containing sargramostim bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank biotech drug Target 2:   UniProt id: P26951 (IL3RA_HUMAN)  -  Interleukin-3 receptor alpha chain
UniProt id: P26951    377 a.a.  
4jzj C,D     250 a.a. 249   X-ray 2.80 Å
There are no PDB entries containing sargramostim bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank biotech drug Target 3:   UniProt id: P32927 (IL3RB_HUMAN)  -  Cytokine receptor common beta chain
UniProt id: P32927    896 a.a.  
1. 3cxe A     412 a.a. 411   X-ray 3.30 Å
  2. 1gh7 A,B     408 a.a. 406   X-ray 3.00 Å
  3. 2gys A,B     397 a.a. 391   X-ray 2.70 Å
  4. 1egj A     101 a.a. 101   X-ray 2.80 Å
  5. 1c8p A     102 a.a. 101   NMR  
There are no PDB entries containing sargramostim bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 4:   UniProt id: P34741 (SDC2_HUMAN)  -  Syndecan-2
UniProt id: P34741    201 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank biotech drug Target 5:   UniProt id: P13727 (PRG2_HUMAN)  -  Bone-marrow proteoglycan
UniProt id: P13727    221 a.a.  
1. 1h8u A,B     115 a.a. 114   X-ray 1.80 Å
  2. 2brs A,B     115 a.a. 114   X-ray 2.20 Å
There are no PDB entries containing sargramostim bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of biotech drug-protein interactions in all selected structures above.

  spacer

spacer