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DB00015 : reteplase

Approved biotech drug reteplase ... 4 targets DB00015

Brand name(s): retavase (centocor), retavase (roche).
UniProt accession: P00750 (TPA_HUMAN)

4
There are 4 target proteins defined in DrugBank for this biotech drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank biotech drug Target 1:   UniProt id: P00747 (PLMN_HUMAN)  -  Plasminogen
UniProt id: P00747    809 a.a.  
1. 4a5t S     767 a.a. 767   X-ray 3.49 Å
  2. 4dur A,B     756 a.a. 756   X-ray 2.45 Å
  3. 4duu A     682 a.a. 682   X-ray 5.20 Å
  4. 1ki0 A     253 a.a. 252   X-ray 1.75 Å
  5. 1bml A,B     250 a.a. 249   X-ray 2.90 Å
   more ...
There are no PDB entries containing reteplase bound to this target protein, although there are 30 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 2:   UniProt id: P02671 (FIBA_HUMAN)  -  Fibrinogen alpha chain
UniProt id: P02671    865 a.a.  
1. 1fzd A,B,C,D,...     197 a.a. 197   X-ray 2.10 Å
  2. 3ghg A,D,G     174 a.a. 174   X-ray 2.90 Å
  3. 1fza A,D     85 a.a. 85   X-ray 2.90 Å
  4. 1fzb A,D     81 a.a. 81   X-ray 2.90 Å
  5. 1fze A,D     81 a.a. 81   X-ray 3.00 Å
   more ...
There are no PDB entries containing reteplase bound to this target protein, although there are 38 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 3:   UniProt id: Q03405 (UPAR_HUMAN)  -  Urokinase plasminogen activator surface receptor
UniProt id: Q03405    334 a.a.  
1. 3bt1 U     273 a.a. 273   X-ray 2.80 Å
  2. 1ywh A,C,E,G,...     268 a.a. 267   X-ray 2.70 Å
  3. 3u73 U     269 a.a. 267   X-ray 3.19 Å
  4. 3u74 U     263 a.a. 261   X-ray 2.39 Å
  5. 2i9b G,H     248 a.a. 244   X-ray 2.80 Å
   more ...
There are no PDB entries containing reteplase bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank biotech drug Target 4:   UniProt id: P05121 (PAI1_HUMAN)  -  Plasminogen activator inhibitor 1
UniProt id: P05121    401 a.a.  
1. 1lj5 A     379 a.a. 379   X-ray 1.80 Å
  2. 1dvn A     379 a.a. 379   X-ray 2.10 Å
  3. 4aqh A,B,C     382 a.a. 379   X-ray 2.40 Å
  4. 1c5g A     379 a.a. 379   X-ray 2.60 Å
  5. 3r4l A     377 a.a. 375   X-ray 2.70 Å
   more ...
There are no PDB entries containing reteplase bound to this target protein, although there are 20 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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