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The two reactions compared are done so using a Tanimoto similarity score (for more information, please see the MACiE FAQ) for the bond changes only. The score maay range from 0 to 1 where 1 indicates that the two reactions are identical at the bond change level and 0 indicates that there are no bond changes in common.


Key

1.0-0.9 0.9-0.8 0.8-0.7 0.7-0.6 0.6-0.5 0.5-0.4 0.4-0.3 0.3-0.2 0.2-0.1 0.1-0.0 =0

Results for Comparison of M0299 and M0296

These two reactions have a combined similarity of 0.82


M0299

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Comparison

M0296

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EC 2.7.7.3
pantetheine-phosphate adenylyltransferase
Serial Number EC 2.7.7.39
glycerol-3-phosphate cytidylyltransferase

Image of ATP

Image of pantetheine 4'-phosphate

right arrow

Image of dephospho-CoA

Image of diphopshate

ATP
C00002
CHEBI:15422
pantetheine 4'-phosphate
C01134
CHEBI:61723
dephospho-CoA
C00882
CHEBI:15468
diphopshate
C00013
CHEBI:45212
1

Image of glycerol-3-phosphate

Image of CTP

right arrow

Image of CDP-glycerol

Image of diphosphate

glycerol-3-phosphate
C00093
CHEBI:15978
CTP
C00063
CHEBI:17677
CDP-glycerol
C00513
diphosphate
C00013
CHEBI:45212

Catalytic CATH Codes

3.40.50.620

Catalytic CATH Codes

3.40.50.620

Active Site



0.29997

Active Site



Catalytic Residues

Type Number Chain Location of Function
Arg 91 A Side Chain
Lys 42 A Side Chain
His 18 A Side Chain
Ser 129 A Main Chain Amide
0.3333

Catalytic Residues

Type Number Chain Location of Function
Lys 44 A Side Chain
Lys 46 A Side Chain

Organic Cofactors

No Associated Organic Cofactors

Organic Cofactors

No Associated Organic Cofactors

Metal Cofactors

Type Het group Number Chain
magnesium No Available PDB Information

Metal Cofactors

Type Het group Number Chain
magnesium No Available PDB Information

Reaction occurs across 1 steps

1

Reaction occurs across 1 steps

Step 1
GIF of Reaction Step M0299.stg01

The phosphate group of pantetheine 4'-phosphate initiates a nucleophilic attack on the alpha phosphate group of ATP in a substitution reaction.
1 Step 1
GIF of Reaction Step M0296.stg01

The glycerol-3-phosphate initiates a nucleophilic attack on the alpha phosphate of CTP in a substitution reaction.

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