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Entry M0313    3.2.2.21    DNA-3-methyladenine glycosylase II

Previous Step

Step 02

The eliminated base deprotonates water, which adds to the DNA.

GIF of Reaction Step M0313.stg02



Mechanisms

Proton Transfer
Bimolecular Nucleophilic Addition

Mechanism Components

Bond Cleavage
Bond Formation
Bond Order Change
Overall Reactant Used
Intermediate Terminated
Overall Product Formed

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Asp228 Side Chain spectator Attractive Charge Charge Interaction
Electrostatic Stabiliser
Tyr222 Side Chain spectator van der Waals interaction
Electrostatic Stabiliser

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
C-O
N-H
O-H
The C-O bond changes from a double to single bond
C
H
N
O

View similar reactions in MACiE.


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