Entry M0281 188.8.131.52 electron-transferring-flavoprotein dehydrogenase
The reduced electron transfer flavoprotein delivers electron to the FAD cofactor via the iron sulfur cluster.
Comment: Mutagenesis and kinetic calculations have shown the electron to relay through the Fe4S4 cluster before reaching the FAD cofactor, rather than being directly donated to the flavin . The electron is relayed to FAD from the iron sulfur cluster through interactions between the close proximity cabronyl of the metal ligand Cys556 and the carbonyl of Arg331 .
Amino acids involved in the reaction step.
Organic Cofactors involved in the reaction step
Metal Cofactors involved in Step 01
||Bonds Changed in Order
||Atom Types Involved
The C-C bond changes from a single to double bond
The C-N bond changes from a double to single bond
The C-O bond changes from a double to single bond
View similar reactions in MACiE.