Entry M0276 188.8.131.52 nitrate reductase
The nitrate oxyanion attacks the molybdenum coordination in a displacement reaction, eliminating the Cys152 sulfur which results in the formation of a disulfide bridge within the coordination sphere.
Comment: Physiological conditions allow an equilibrium between Mo(V) and Mo(VI) to exist . The conformational change adopted by the coordination sphere on addition of the nitrate molecule is stabilised by the steric bulk and electronic charge delocalisation resulting from the position of Met308 and Met141 .
Amino acids involved in the reaction step.
Organic Cofactors involved in the reaction step
Metal Cofactors involved in Step 01
||Bonds Changed in Order
||Atom Types Involved
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