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Entry M0263    4.2.3.37    epi-isozizaene synthase

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Step 06

Intramolecular electrophilic addition to form the second six-membered ring.

GIF of Reaction Step M0263.stg06



Mechanisms

Intramolecular Electrophilic Addition

Mechanism Components

Bond Formation
Bond Order Change
Intermediate Formation
Cyclisation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Arg338 Side Chain spectator Electrostatic Stabiliser
Promotes Heterolytic Reactions
Hydrogen Bond Donor
Phe95 Side Chain spectator Steric Role
Electrostatic Stabiliser
Polar Non-polar interaction
Phe96 Side Chain spectator Steric Role
Electrostatic Stabiliser
Polar Non-polar interaction
Phe198 Side Chain spectator Steric Role
Electrostatic Stabiliser
Polar Non-polar interaction

Metal Cofactors involved in Step 06

Metal Type Metal Identity Chain Activity Function
magnesium MG 700 A spectator Substrate Binding
Electrostatic Stabiliser
magnesium MG 701 A spectator Substrate Binding
Electrostatic Stabiliser
magnesium MG 702 A spectator Substrate Binding
Electrostatic Stabiliser

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
C-C
None
The C-C bond changes from a double to single bond
C

View similar reactions in MACiE.


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