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Entry M0263    4.2.3.37    epi-isozizaene synthase

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Step 04

A 1,2-Hydride shift.

GIF of Reaction Step M0263.stg04


Comment: A 1,2 Hydride shift



Mechanisms

Hydride Transfer
Intramolecular Rearrangement

Mechanism Components

Bond Formation
Bond Cleavage
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Arg338 Side Chain spectator Electrostatic Stabiliser
Promotes Heterolytic Reactions
Hydrogen Bond Donor
Phe95 Side Chain spectator Steric Role
Electrostatic Stabiliser
Polar Non-polar interaction
Phe96 Side Chain spectator Steric Role
Electrostatic Stabiliser
Polar Non-polar interaction
Phe198 Side Chain spectator Steric Role
Electrostatic Stabiliser
Polar Non-polar interaction

Metal Cofactors involved in Step 04

Metal Type Metal Identity Chain Activity Function
magnesium MG 700 A spectator Substrate Binding
Electrostatic Stabiliser
magnesium MG 701 A spectator Substrate Binding
Electrostatic Stabiliser
magnesium MG 702 A spectator Substrate Binding
Electrostatic Stabiliser

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
C-H
C-H
None
C
H

View similar reactions in MACiE.


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