Entry M0262 184.108.40.206 trichodiene synthase
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Intramolecular elimination of the pyrophosphate.
Comment: Free rotation about the C2-C3 bond from the transoid to cisoid conformation orientates the empty p orbital of C1 in the cation towards the C6-C7 pi orbital to facilitate the C1-C6 bond formation. It is currently unclear is this is concomitant with, or prior to the dipohsphate departure . The positive charge of carbo cation delocalised over the three terminal carbon atoms. It is likely that the phosphate remains bound and aids in electrostatic stabilisation of the reaction intermediates .
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 03
||Bonds Changed in Order
||Atom Types Involved
The C-C bond changes from a single to double bond
The C-C bond changes from a double to single bond
View similar reactions in MACiE.