Entry M0262 220.127.116.11 trichodiene synthase
The binding of the substrate causes a conformation change in the active site, which promotes the elimination of the pyrophosphate.
Comment: The substrate is ionised by the dipohsphate interactions with the Mg(II) ions, Arg304, Lys232, Arg182 and Tyr305. Positive charge of carbo cation delocalised over the three terminal carbon atoms.
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 01
||Bonds Changed in Order
||Atom Types Involved
The C-C bond changes from a single to double bond
The C-C bond changes from a double to single bond
View similar reactions in MACiE.