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Entry M0236    4.1.1.85    3-dehydro-L-gulonate-6-phosphate decarboxylase

Previous Step

Step 03

An acid, assumed to be water, protonates His136.

This reaction step has been inferred

GIF of Reaction Step M0236.stg03


Comment: Inferred return step.



Mechanisms

Proton Transfer

Mechanism Components

Bond Cleavage
Bond Formation
Enzyme Regenerated

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
His136A Side Chain reactant Proton Acceptor
Hydrogen Bond Donor
Hydrogen Bond Acceptor
Asp67B Side Chain spectator Not Active
Glu112A Side Chain spectator Increase Basicity
Hydrogen Bond Acceptor
Lys64A Side Chain spectator Not Active

Metal Cofactors involved in Step 03

Metal Type Metal Identity Chain Activity Function
magnesium MG 5300 _ spectator Not Active

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
N-H
O-H
None
H
N
O

View similar reactions in MACiE.


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