Entry M0234 184.108.40.206 GMP synthase (glutamine-hydrolysing)
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Ammonia is deprotonated by the phosphate of the intermediate, activating it for a nucleophilic attack on the intermediate, which liberates AMP and the GMP product.
Comment: Reaction occurs in the ATP pyrophosphatase domain (CATH 220.127.116.110). It is assumed that the phosphate acts as the general base, and that the magnesium ion stabilises the pentacoordinate transition state.
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 04
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||Atom Types Involved
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