EC Number: 184.108.40.206 (A member of the Transferases, Transferring phosphorus-containing groups, Phosphotransferases with an alcohol group as acceptor)
Enzyme Name: adenosine kinase
Biological Species: Toxoplasma gondii (Bacteria)
Catalytic Chain UniprotKB Accession Codes:
Representative PDB Code: 1lij - STRUCTURE OF T. GONDII ADENOSINE KINASE BOUND TO PRODRUG 27-IODOTUBERCIDIN AND AMP-PCP (Resolution = 1.86 Å).
Overall Comment: Upon adenosine binding, a conserved dipeptide Gly68-Gly69 at the active site triggers a rigid-body rotation of 30 degrees of the lid domain, resulting in occlusion of the adenosine and the gamma-phosphate of ATP from the solvent. The reaction is ordered with adenosine binding first. This binding results in structural changes which are required in order for ATP to bind. The binding of ATP induces the formation of an anion hole, which completes the structural requirements for catalysis . Although a chloride ion is bound in the active site, its role, if any, is unknown .
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Stepwise Description of the Reaction
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Catalytic Residues Involved
Metal Cofactors for M0209
Homologue information for M0209 (1lij)
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