Entry M0201 188.8.131.52 propionyl-CoA carboxylase
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Reaction occurs in the beta-subunit. The oxyanion re-forms the carbonyl group, causing the C=N bond of the activated biotin to deprotonate the propanoyl-CoA with concomitant tautomerisation. The main chain amides of Gly182 and Gly183 stabilise the activated propanoyl-CoA, the main chain amides of Gly419B and Ala420B stabilise the oxyanion of the activated biotin.
Comment: This step occurs in the beta-subunit, the carboxytransferase domain.
Amino acids involved in the reaction step.
Organic Cofactors involved in the reaction step
Metal Cofactors involved in Step 06
||MG(not in PDB) 1
||Bonds Changed in Order
||Atom Types Involved
The C-C bond changes from a single to double bond
The C-O bond changes from a single to double bond
The C-N bond changes from a double to single bond
The C-O bond changes from a double to single bond
View similar reactions in MACiE.