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Entry M0200    6.3.1.5    NAD+ synthase

Next Step

Step 01

Carboxylate group of the deamino-NAD acts as a nucleophile and attacks the gamma-phosphate of the ATP in a substitution reaction, liberating pyrophosphate. The two Mg(II) ions stabilise the intermediates formed

GIF of Reaction Step M0200.stg01



Mechanisms

Bimolecular Nucleophilic Substitution

Mechanism Components

Overall Reactant Used
Bond Formation
Bond Cleavage
Intermediate Formation
Overall Product Formed

Amino acids involved in the reaction step.

There are no amino acid residues associated with this reaction step


Metal Cofactors involved in Step 01

Metal Type Metal Identity Chain Activity Function
magnesium MG 5001 x spectator Substrate Binding
Activator
Increase Electrophilicity
Electrostatic Stabiliser
magnesium MG 5002 x spectator Substrate Binding
Activator
Increase Electrophilicity
Electrostatic Stabiliser

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
P-O
P-O
None
O
P

View similar reactions in MACiE.


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