Entry M0196 18.104.22.168 chalcone isomerase
The chalcone substrate undergoes an intramolecular nucleophilic addition, and deprotonates a water molecule to generate the flavanone product.
Comment: The cyclisation reaction proceeds through a transition state in which charge delocalisation results in the transient protonation of the transition state enolate by the water molecule hydrogen bonded to Tyr106 [1,2].
Amino acids involved in the reaction step.
||Bonds Changed in Order
||Atom Types Involved
The C-C bond changes from a double to single bond
View similar reactions in MACiE.