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Overview for MACiE Entry M0193

Version history

General Information

EC Number: 5.4.1.2 (A member of the Isomerases, Intramolecular transferases, Transferring acyl groups)

Enzyme Name: precorrin-8X methylmutase

Biological Species: Pseudomonas denitrificans (Bacteria)

Catalytic Chain UniprotKB Accession Codes:

  • P21638 - Precorrin-8X methylmutase

Representative PDB Code: 1f2v - CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBICVITAMIN B12 SYNTHESIS (Resolution = 2.10 Å).

Catalytic CATH Codes:

Display structure information

Overall Reaction:

Image of precorrin 8X

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Image of hydrogenobyrinate

precorrin 8X
C06408
CHEBI:28629
hydrogenobyrinate
C06399
CHEBI:17926

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Stepwise Description of the Reaction

Step 1The nitrogen of one of the precorrin 8X rings deprotonates His43.
Step 2The protonated ring then undergoes a sigmatropic rearrangement.
Step 3His43 deprotonates the ring, resulting in the hydrogenobyrinate product.

View similar reactions (composite manual annotation)


Catalytic Residues Involved

Type Number Chain Location of Function
His 43 A Side Chain

References

  1. L. W. Shipman et al. (2001), Structure, 9, 587-596. Crystal structure of precorrin-8x methyl mutase.
    Medline: 11470433

Homologue information for M0193 (1f2v)

CSA Homologues

MACiE Homologues (within the PDB)

MACiE Homologues (within UniprotKB/SwissProt)


Links to this entry in other databases

Link to EC-PDB-SUM Link to PDB-SUM Link to RCSB PDB Link to PDBe Link to CSA
Link to MetaCyc Link to KEGG Link to BRENDA Link to ExplorENZ

GOA logo
cobalamin biosynthetic process (biological process)
isomerase activity (molecular function)
precorrin-8X methylmutase activity (molecular function)
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